The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability

J Van der Merwe, J Steenekamp, D Steyn, J Hamman - Pharmaceutics, 2020 - mdpi.com
… ) exhibit poor solubility and low dissolution rates in aqueous … low as a result of their poor
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …

[PDF][PDF] Solubility enhancement of poorly water soluble drugs: A review

P Kesarwani, S Rastogi, V Bhalla, V Arora - International Journal of …, 2014 - Citeseer
dissolution rate by increasing the surface area through particle size reduction of poorly soluble
drugs results in poor … For improvement of solubility and dissolution rate, we can change in …

Inorganic matrices: an answer to low drug solubility problem

L Perioli, C Pagano - Expert opinion on drug delivery, 2012 - Taylor & Francis
… to improve solubility and dissolution rate of … poor oral bioavailability is the most considerable
cause responsible for this trend Citation[1]. Many studies highlighted that the poor solubility

Controlled suspensions enable rapid determinations of intrinsic dissolution rate and apparent solubility of poorly water-soluble compounds

SBE Andersson, C Alvebratt, CAS Bergström - Pharmaceutical research, 2017 - Springer
poor dissolution and is dissolution rate-limited when a particle size >2 μm is used, based
on a dose of 25 mg. Owing to the poor solubility of cinnarizine, the compound is also solubility-…

Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate

M Abdur Rouf, I Vural, E Bilensoy, A Hincal… - Journal of Inclusion …, 2011 - Springer
… to improve poor aqueous solubility and dissolutionsolubility analysis and in vitro dissolution
studies. According to the characterization data for the complexes, rapamycin water solubility

Co-solvent Evaporation Method for Enhancement of Solubility and Dissolution Rate of Poorly Aqueous Soluble Drug Simvastatin: In vitroIn vivo Evaluation

P Pandya, S Gattani, P Jain, L Khirwal, S Surana - AAPS pharmscitech, 2008 - Springer
… to poor aqueous solubility, and these molecules become unsuccessful to reach the market.
Thus, enhancement of aqueous solubility, dissolution rate… having poor aqueous solubility and …

Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs

XY Lawrence, AS Carlin, GL Amidon… - International journal of …, 2004 - Elsevier
dissolution rate (DIDR) to determine solubility class membership. We employed a VanKel
dissolution … In many cases, these assumptions may not be met due to poor wetting, pH changes…

Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-β-cyclodextrin

BJ Lee, JR Lee - Archives of pharmacal research, 1995 - Springer
… with 2-HPI3CD were prepared to enhance solubility and dissolution rate. It was known that
utilization of NPX was limited because of poor bioavailability and undesirable gastrointestinal …

Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients

A Hussain, G Smith, KA Khan, NI Bukhari… - European Journal of …, 2018 - Elsevier
… , excipient and drug molecules) and the dissolution rate (including the relaxation time of …
in poor bioavailability when administered as a conventional dosage form. The poor solubility of …

Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties

VR Gupta, S Mutalik, MM Patel, GK Jani - Acta pharmaceutica, 2007 - hrcak.srce.hr
… and poor oral bioavailability due to low aqueous solubility (5)… of celecoxib but the aqueous
solubility of spherical crystallized … improve aqueous solubility and dissolution rates in addition …