The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
… ) exhibit poor solubility and low dissolution rates in aqueous … low as a result of their poor
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …
[PDF][PDF] Solubility enhancement of poorly water soluble drugs: A review
… dissolution rate by increasing the surface area through particle size reduction of poorly soluble
drugs results in poor … For improvement of solubility and dissolution rate, we can change in …
drugs results in poor … For improvement of solubility and dissolution rate, we can change in …
Inorganic matrices: an answer to low drug solubility problem
L Perioli, C Pagano - Expert opinion on drug delivery, 2012 - Taylor & Francis
… to improve solubility and dissolution rate of … poor oral bioavailability is the most considerable
cause responsible for this trend Citation[1]. Many studies highlighted that the poor solubility …
cause responsible for this trend Citation[1]. Many studies highlighted that the poor solubility …
Controlled suspensions enable rapid determinations of intrinsic dissolution rate and apparent solubility of poorly water-soluble compounds
… poor dissolution and is dissolution rate-limited when a particle size >2 μm is used, based
on a dose of 25 mg. Owing to the poor solubility of cinnarizine, the compound is also solubility-…
on a dose of 25 mg. Owing to the poor solubility of cinnarizine, the compound is also solubility-…
Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate
M Abdur Rouf, I Vural, E Bilensoy, A Hincal… - Journal of Inclusion …, 2011 - Springer
… to improve poor aqueous solubility and dissolution … solubility analysis and in vitro dissolution
studies. According to the characterization data for the complexes, rapamycin water solubility …
studies. According to the characterization data for the complexes, rapamycin water solubility …
Co-solvent Evaporation Method for Enhancement of Solubility and Dissolution Rate of Poorly Aqueous Soluble Drug Simvastatin: In vitro–In vivo Evaluation
… to poor aqueous solubility, and these molecules become unsuccessful to reach the market.
Thus, enhancement of aqueous solubility, dissolution rate… having poor aqueous solubility and …
Thus, enhancement of aqueous solubility, dissolution rate… having poor aqueous solubility and …
Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs
XY Lawrence, AS Carlin, GL Amidon… - International journal of …, 2004 - Elsevier
… dissolution rate (DIDR) to determine solubility class membership. We employed a VanKel
dissolution … In many cases, these assumptions may not be met due to poor wetting, pH changes…
dissolution … In many cases, these assumptions may not be met due to poor wetting, pH changes…
Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-β-cyclodextrin
BJ Lee, JR Lee - Archives of pharmacal research, 1995 - Springer
… with 2-HPI3CD were prepared to enhance solubility and dissolution rate. It was known that
utilization of NPX was limited because of poor bioavailability and undesirable gastrointestinal …
utilization of NPX was limited because of poor bioavailability and undesirable gastrointestinal …
Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients
A Hussain, G Smith, KA Khan, NI Bukhari… - European Journal of …, 2018 - Elsevier
… , excipient and drug molecules) and the dissolution rate (including the relaxation time of …
in poor bioavailability when administered as a conventional dosage form. The poor solubility of …
in poor bioavailability when administered as a conventional dosage form. The poor solubility of …
Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties
… and poor oral bioavailability due to low aqueous solubility (5)… of celecoxib but the aqueous
solubility of spherical crystallized … improve aqueous solubility and dissolution rates in addition …
solubility of spherical crystallized … improve aqueous solubility and dissolution rates in addition …