Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals

SB Murdande, DA Shah, RH Dave - Journal of pharmaceutical sciences, 2015 - Elsevier
… In the present study, the dissolution rate was examined in different nonsink conditions, 29
for efficient discrimination of the dissolution rate enhancement with mean particle sizes that …

Micronization by rapid expansion of supercritical solutions to enhance the dissolution rates of poorly water-soluble pharmaceuticals

M Charoenchaitrakool, F Dehghani… - Industrial & …, 2000 - ACS Publications
… to micronize racemic ibuprofen, and the dissolution rate of the micronized product in a buffered
… used as a model drug because its dissolution rate is limited by its poor solubility in water. …

[HTML][HTML] Nanosizing of drugs: effect on dissolution rate

SM Dizaj, Z Vazifehasl, S Salatin… - … in pharmaceutical …, 2015 - journals.lww.com
… methods to increase the dissolution rate of poorly water soluble drugs. In this … dissolution
rate of poorly aqueous soluble drugs. According to the reviewed literature, by reduction of drug

[PDF][PDF] Dissolution testing for poorly soluble drugs: a continuing perspective

K Gowthamarajan, SK Singh - Dissolution Technologies, 2010 - Citeseer
… Although natural cyclodextrin, especially the β-type, has been utilized extensively to improve
the dissolution rate and absorption of insoluble drug molecules, Uekama and others have …

Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs

DN Bikiaris - Expert opinion on drug delivery, 2011 - Taylor & Francis
poorly soluble drug at reduced particle sizes and this apparently increases the dissolution
rate … improve the dissolution and bioavailability of poorly water-soluble drug was investigated. …

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

N Blagden, M de Matas, PT Gavan, P York - Advanced drug delivery …, 2007 - Elsevier
… for improving the solubility, dissolution rate and subsequent bioavailability of poorly
soluble drugs. The ability to engineer materials with suitable dissolution characteristics, whilst …

Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels

I Smirnova, S Suttiruengwong, M Seiler… - Pharmaceutical …, 2005 - Taylor & Francis
… can be used for poorly water soluble drugs, whose immediate release into the biological
environment is desired. The dissolution of both ketoprofen and griseofulvin from drug‐aerogel …

Wetting kinetics: an alternative approach towards understanding the enhanced dissolution rate for amorphous solid dispersion of a poorly soluble drug

S Verma, VS Rudraraju - Aaps Pharmscitech, 2015 - Springer
drug forms using solid dispersions is highly attractive for enhancing the dissolution rate of
poorly soluble … solid dispersions, still only few drug products based on solid dispersions have …

Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals

MT Crisp, CJ Tucker, TL Rogers, RO Williams III… - Journal of Controlled …, 2007 - Elsevier
… The dissolution of a poorly soluble drug by surfactant occurs through a series of interfacial
steps [14], [17] including: (1) diffusion of surfactant from the bulk fluid to the particle surface, (2) …

[HTML][HTML] Evaluation of poorly soluble drugs' dissolution rate by laser scattering in different water isotopologues

EV Uspenskaya, TV Pleteneva, IV Kazimova… - Molecules, 2021 - mdpi.com
… The oral bioavailability depends on several factors including aqueous solubility, drug
permeability, dissolution rate, first-pass metabolism, presystemic metabolism, and susceptibility to …