Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals
… In the present study, the dissolution rate was examined in different nonsink conditions, 29
for efficient discrimination of the dissolution rate enhancement with mean particle sizes that …
for efficient discrimination of the dissolution rate enhancement with mean particle sizes that …
Micronization by rapid expansion of supercritical solutions to enhance the dissolution rates of poorly water-soluble pharmaceuticals
M Charoenchaitrakool, F Dehghani… - Industrial & …, 2000 - ACS Publications
… to micronize racemic ibuprofen, and the dissolution rate of the micronized product in a buffered
… used as a model drug because its dissolution rate is limited by its poor solubility in water. …
… used as a model drug because its dissolution rate is limited by its poor solubility in water. …
[HTML][HTML] Nanosizing of drugs: effect on dissolution rate
… methods to increase the dissolution rate of poorly water soluble drugs. In this … dissolution
rate of poorly aqueous soluble drugs. According to the reviewed literature, by reduction of drug …
rate of poorly aqueous soluble drugs. According to the reviewed literature, by reduction of drug …
[PDF][PDF] Dissolution testing for poorly soluble drugs: a continuing perspective
K Gowthamarajan, SK Singh - Dissolution Technologies, 2010 - Citeseer
… Although natural cyclodextrin, especially the β-type, has been utilized extensively to improve
the dissolution rate and absorption of insoluble drug molecules, Uekama and others have …
the dissolution rate and absorption of insoluble drug molecules, Uekama and others have …
Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs
DN Bikiaris - Expert opinion on drug delivery, 2011 - Taylor & Francis
… poorly soluble drug at reduced particle sizes and this apparently increases the dissolution
rate … improve the dissolution and bioavailability of poorly water-soluble drug was investigated. …
rate … improve the dissolution and bioavailability of poorly water-soluble drug was investigated. …
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
N Blagden, M de Matas, PT Gavan, P York - Advanced drug delivery …, 2007 - Elsevier
… for improving the solubility, dissolution rate and subsequent bioavailability of poorly
soluble drugs. The ability to engineer materials with suitable dissolution characteristics, whilst …
soluble drugs. The ability to engineer materials with suitable dissolution characteristics, whilst …
Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels
I Smirnova, S Suttiruengwong, M Seiler… - Pharmaceutical …, 2005 - Taylor & Francis
… can be used for poorly water soluble drugs, whose immediate release into the biological
environment is desired. The dissolution of both ketoprofen and griseofulvin from drug‐aerogel …
environment is desired. The dissolution of both ketoprofen and griseofulvin from drug‐aerogel …
Wetting kinetics: an alternative approach towards understanding the enhanced dissolution rate for amorphous solid dispersion of a poorly soluble drug
S Verma, VS Rudraraju - Aaps Pharmscitech, 2015 - Springer
… drug forms using solid dispersions is highly attractive for enhancing the dissolution rate of
poorly soluble … solid dispersions, still only few drug products based on solid dispersions have …
poorly soluble … solid dispersions, still only few drug products based on solid dispersions have …
Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals
MT Crisp, CJ Tucker, TL Rogers, RO Williams III… - Journal of Controlled …, 2007 - Elsevier
… The dissolution of a poorly soluble drug by surfactant occurs through a series of interfacial
steps [14], [17] including: (1) diffusion of surfactant from the bulk fluid to the particle surface, (2) …
steps [14], [17] including: (1) diffusion of surfactant from the bulk fluid to the particle surface, (2) …
[HTML][HTML] Evaluation of poorly soluble drugs' dissolution rate by laser scattering in different water isotopologues
EV Uspenskaya, TV Pleteneva, IV Kazimova… - Molecules, 2021 - mdpi.com
… The oral bioavailability depends on several factors including aqueous solubility, drug
permeability, dissolution rate, first-pass metabolism, presystemic metabolism, and susceptibility to …
permeability, dissolution rate, first-pass metabolism, presystemic metabolism, and susceptibility to …
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