… of peptides selected and presented by class II MHC molecules and their recognition by CD4
+ T cells. The nature of peptides selected by MHC … for their binding to MHC molecules, the …

… peptide bound to a particular class I or class I1 MHC molecule, and a T cell selected by one
combination of peptide plus MHC … in terms of the diversity of human class I MHC molecules, …

… of protein antigens and the site of peptide binding to MHC class II molecules. These subtle
… ways a diverse peptide repertoire is displayed on the APC surface. This diversity may have …

… express diverse TCR-Vβ chains, while subdominant peptide-… peptides that form stable
complexes with MHC molecules elicit dominant T cell responses characterized by a diverse …

… structure of all peptide‐MHC complexes is infeasible, an … peptide, (2) predicting subtle
changes in the MHC interface geometry upon binding, and (3) building models for numerous MHC …

… Initial studies reported that up to 30% of MHC class I-associated peptides by diversity and
25% by mass were created by splicing 89 , with a similar fraction independently reported by …

… lead to the diversity of antigens presented by MHC class I … antigen peptides; and cross-recognition
of antigenic peptides by … the TCR, peptide, and MHC, leading to a high diversity in the …

… atoms of the antigenic peptide) are different in classical class I and class II molecules, but …
Also, a 1 domains are generally less diverse (and even monomorphic in some class II …

… I molecules of the major histocompatibility complex (MHC) bind peptides … peptides at the
cell surface. Cytotoxic T lymphocytes (CTLs) examine the diverse array of surface peptide-class-…

… Class I major histocompatibility complex (MHC) molecules interactwith self and foreign
peptides of diverse amino acid sequences yet exhibit distinct allele-specific selectivity for …