… correlation of Dkk-1 levels with IL-6 levels observed in vivo in the inflamed joints of RA and
SpA patients is mirrored by the differential regulation of Dkk-1 production by TNF and IL-6 in …

… interleukin-6 (IL-6), which stimulates the proliferation of Dkk1-secreting MM cells. Finally, we
show that use of a Dkk1-blocking agent, such as 6-… cycle induced by Dkk1, which may also …

… (IL-6/IL-6R, TNFα, and DKK-1) was less efficient than the combination of IL-6 and DKK-1 (…
any effect in combination with DKK-1 or in combination with IL-6/IL-6R and DKK-1 together. …

… cullin associated and neddylation dissociated 1 from hampering the assembly of … interleukin-6
(IL-6) stimulated CKAP4 expression to generate drug resistance, and disturbance of DKK1-…

… that FLS suppress Wnt signal via DKK1 production, and that both IL-1β and IL-6 reduce DKK1
production from the cells and, thereby, activate Wnt signaling (Figs. 1 and 4). Consistently, …

… co-receptor protein LRP5/6, and thus inhibits Wnt signaling. DKK-1 is expressed by many …
By stimulating the production of DKK-1 in myeloma cells, IL-6 prevents the differentiation of …

… of DKK1 and IL-6, 46 while in the present study, there were significant and positive
correlations between IL-6 and DKK1. Nevertheless, one study reported lowered DKK1 and …

… of Dkk-1 and SOST at 0, 1, 6 and 24 h after TNF exposure showed that induction of Dkk-1
starts after 6 … Moreover, blockade of Dkk-1 prevented TNF-mediated downregulation of alkaline …

… DKK1 is a negative regulator of Wnt signaling pathway, in the present study we found DKK1
… biological functions of DKK-1 in cancer biology as showed by loss of DKK1 expression as a …

… We first aimed to assess DKK-1 gene expression and Wnt pathway activity in MSCs from
AS patients compared to healthy controls. We found that DKK-1 was significantly …