… This paper describes experiments involving the measurement of DNA damage and …
mammalian cell cultures primarily associated with defects in the excision repair of UV-induced DNA …

… et al., 1994), emphasizing the importance of mutagenicity studies in eukaryotic cells. We
report here that εdA is a strongly mutagenic DNA adduct when replicated in mammalian cells. …

… Generation of oxidized bases by reaction of DNAwith intracellular oxidants is quantitatively
the most important class of base modification occurring in mammalian cells. Estimates of the …

… arsenite-induced DNA damage. We conclude that arsenite induces DNA adducts through
calcium-mediated production of peroxynitrite, hypochlorous acid, and hydroxyl radicals. …

… biological effects of individual adducts in various mammalian cell cultures, observed in the …
that various adducts are capable of inducing different cell death pathways in cancer cells.This …

… DNA damage induced by AA and GA in mammalian cells, using V79 Chinese hamster
cells. … (SCEs), as well as the levels of specific GA-DNA adducts, namely, N7-(2-carbamoyl-2-…

… A number of different methods have been developed to detect and measure DNA adducts in
… agents on DNA adduct level. AMS has been used to measure DNA adducts in human tissue …

… cal structure of the adduct, the sequence context of … adduct that is present in the replication
fork complex. In this study, the cellular mutagenicity of two structurally related DNA adducts …

… on platinum adduct repair in prokaryotes, comparatively little information is available about
analogous pathways in mammalian cells. It is known that, when mammalian cells are treated …

… as strongly as cisplatin in various mammalian cells. Using repair-defective nucleotide … –deficient
cells, we show that NER is mainly responsible for removal of pyriplatin–DNA adducts. …