… of DNA adducts formed from NNK. In addition, it provides evidence that multiple adducts …
The adduct that contributes to the genotoxic effects of NNK depends on the context, such as …

… DNA adduct formation by tobacco-specific nitrosamines is dependent on metabolic activation.
In this paper, metabolic activation and DNA adduct formation by NNK, NNAL, and NNN …

… metabolism and DNA interactions of these nitrosamines, while … of NNK and NNN metabolism
and DNA adduct formation has … on the metabolism and DNA interactions of NNK and NNN. …

… We have developed methods to measure hemoglobin and DNA adducts of NNK andNNN
in humans. We discuss these studies and describe parallel research in laboratory animals …

… understanding the effects of carcinogenic nitrosamines such as NNK, NNAL, and NNN. All
… adducts and DNA adducts has been established in F-344 rats treated with a range of NNK …

… for their detection of DNA from in vivo sources. Table 1 displays the levels of pyridyloxobutyl
DNA adducts detected in lung and liver DNA following four subcutaneous doses of NNK [51]…

… during DNA replication. (2-4) Hecht and co-workers (4, 5) found that NNK and NNN, after
metabolic … that can pyridyloxobutylate DNA, and that of NNK can also lead to the methylation of …

… Formation of NNK derived DNA adducts requires metabolic … Since the pyridyloxobutyl DNA
adducts produced by NNKOAc … ) released by acid hydrolysis of the DNA (Hecht et al., 1988). …

… of POB-DNA adducts, most likely from the major adduct N 7 POBdG quantified here, although
we cannot exclude the contribution of 7-methyl-dG from NNK which can depurinate but …

… induced by NNK cannot be attributed to either the local concentration of DNA adducts or
to the NNK itself. At present, the mechanism for this selective toxicity is not under stood. …