… nitrogen mustards with all the DNA bases has not yet been reported theoretically. Such a
study may be useful for new anti-cancer … of aziridinium ion of mechlorethamine, that can serve …

… to nitrogen mustard derivatives [4]. The aliphatic nitrogen mustard Mechlorethamine was …
drugs show their action by cross-linking the DNA base pairs viz. guanine, adenine, cytosine, …

… by the DNA molecule (nitrogenous base or phosphodiester … the attachment of the second
base of DNA (act as a nucleophile… of Nitrogen mustard, such as mechlorethamine, chlorambucil …

… GC base pairs have confirmed that nitrogen mustard derivative like chlorambucil attacks …
Future studies on designing cell specific anti cancer drugs based on nitrogen mustards are …

… of nitrogen mustards (mechlorethamine, chlorambucil, melphalan, cyclophosphamide and
steroidal based nitrogen mustards). … of nitrogen mustards that includes DNA directed nitrogen …

… of nitrogen mustards includes DNA binding and cross-linking, thus preventing DNA … ,
ovarian and uterine cancer cells than the parental chlorambucil. Introduction of tyrosine entity to …

… Nitrogen mustards are nonspecific DNA alkylating agents. … of a class of platinum-containing
anti-cancer drugs, which now … induced by the nitrogen mustard mechlorethamine on human …

… of the nitrogen mustards has been described in detail, as previously noted, with mechlorethamine
… agent of DNA bases, as well as a mutagen, and a DNA-protein crosslinker [22, 43-46]. …

… ) of a DNA triple helix that orients the chlorambucil adjacent to … using DNA-bound chlorambucil
and benzoic acid mustard … anticancer utility, this work demonstrates that the nitrogen …

… Derivatives still used today are the aniline mustards chlorambucil (2) and melphalan (… DNA
bases. 4 The rates of the various reactions of nitrogen mustards (hydrolysis, alkylation of DNA…