… topoisomerase II with DNA damage. Since the DNA cleavage and ligation reactions of
topoisomerase … focus on the DNA cleavage and ligation reactions of topoisomerase II and agents …

… the covalent topoisomerase II-DNA cleavage complex, their … -DNA complex, the effect of
etoposide on the DNA cleavage/religation reaction of Drosophila melanogaster topoisomerase II …

… Apurinic sites, apyrimidinic sites, base mismatches, and ultraviolet photoproducts all enhance
topoisomerase I-mediated DNA cleavage when they are located in close proximity to the …

… The DNA cleavage reaction of eukaryotic topoisomerase II produces nicked DNA along with
… Therefore, relationships between the enzyme’s DNA nicking and double-stranded cleavage …

… II can be trapped as a DNA-enzyme covalent complex containing DNA with doublestranded …
DNA cleavage by topoisomerase II proceeds by two asymmetric single-stranded cleavage …

… Bacterial type IIA topoisomerase inhibitors, such as fluoroquinolones and … topoisomerase
inhibitors, can trap DNA cleavage complexes with double- or single-stranded cleaved DNA. To …

… structures of eukaryotic DNA, we have purified DNA topoisomerase … between mammalian
DNA topoisomerase I1 and DNA. … Very little double-stranded DNA cleavage was observed with …

… topoisomerase II mediated DNA cleavage. In order to more fully characterize the DNA
cleavage … that generates high levels of topoisomerase II mediated DNA cleavage, even in the …

… drug class inhibit gyrase-mediated DNA religation (61). A … DNA strand passage activity of
eukaryotic topoisomerase I1 (32… , stimulate DNA cleavage mediated by the eukaryotic enzyme (…

… thecin has been proposed to form a ternary complex with enzyme and DNA by binding
reversibly at the DNA cleavage site after establishment of the covalent topoisomerase I-DNA …