… In this work, we extended such models to predict the pattern of radiation-induced DNA
damage detected by protein markers in biological images after taking into account the optical …

… However, the effect that postmortem damage has on endogenous DNA is often underrated.
The majority of postmortem DNA damage occurs as double-strand breaks and oxidative …

… In the parallel paper 1, we describe analysis of the pattern of … of DNA damage signaling,
likely representing sites of DNA double-strand breaks; DSBs) and the nearest DNA replication …

… In addition to the p53-dependent damage response, the … kinetics of p21 induction by
DNA damage and serum stimulation and … –repair displayed a distinct pattern of detergent-insoluble …

… heterogeneous damage distribution is caused by variations in formation or repair of DNA
damage. … A heterogeneous pattern of oxidative DNA damage along the mtDNA was previously …

… linked to the initial DNA damage distribution induced by radiation rather than the local
dose distribution itself. We assume that the microscopic spatial distribution of DNA damage, …

… There are problems in extrapolating these data to the assignment of complexities of damage
in cellular DNA and its associated waters: (1) while energy deposition patterns in DNA may …

… lesion patterns causing cell inactivation. We find that clustering of DNA damage on both
the nm and µm scale leads to enhanced inactivation compared to more homogeneous lesion …

… The typical focal S-phase distribution pattern outside the damage remains unaffected,
suggesting that in spite of potential local differences in nuclear architecture, PCNA readily gains …

… genotoxins, tumour-specific mutation patterns and chromatin organisation and transcriptional
… outcomes of DNA damage, will improve our understanding of the role of DNA damage in …