… cruzi activate several responses that promote unbalance of reactive oxygen species (ROS)
that may cause DNA damage that activate cellular responses including DNA … infected with T. …

… BER is essential to combat oxidative DNA damage during parasite nuclear DNA replication
[58]. The Tritryps genomes apparently do not encode for the other X-family polymerases, …

… cruzi. We establish that ROS/RNS generate nuclear and kinetoplastid DNA damage in T.
cruzi that may be partially repaired by the parasite. Furthermore, we determined that both …

… We conducted a comparative analysis of the DNA damage response of T. cruzi and L. major
parasites to double-strand breaks induced by two different methods. We compared genome-…

… cruzi coincided with enhanced DNA damage in the host cell. We studied the engagement
of the DNA damage … ) pathways at the different time points (0–24 h post-infection, hpi) by T. …

… This oxidant species can lead to lipid peroxidation (interfering with membrane integrity),
DNA damage (causing strand breaks or chemically changing nitrogen bases), as well as …

… interest in the parasite’s DNA metabolism against natural and artificial DNA damage-causing
insults [16,17]. In the current review, we will go through the main strategies used by the …

… The QPCR technique was employed to compare the extent of DNA damage in the genome
of the parasite populations used in this work. The normalized amplification of pROCK cells …

… Since TcRad51 does not appear to be involved in the repair of crosslink DNA damage, we
decided to evaluate the contribution of TcRad51 to the cellular response against oxidative …

… Because we could not detect a high amount of BZ-induced DNA damage using the QPCR
assays, we analyzed the nuclear and mitochondrial ultrastructure by transmission electron …