… cancer and created DNA methylation “cityscape” plots to visualize these complex data. We
show that somatic DNA methylation alterations, … with lethal metastatic prostate cancer, were …

… DNA methylation is a key regulator of gene expression, the comprehensive methylation
landscape of metastatic cancer … resistant prostate metastases, we discovered alterations affecting …

… Here, we present the DNA methylation landscapes of a cohort of 42 patients with brain
metastases from prostate cancer, complementing our recent study on the genetic landscapes of …

… carcinogenesis; some correlate with pathological grade or clinical stage of prostate
cancer; some contribute to invasiveness, metastasis and androgen independence of …

… We will therefore discuss in turn altered DNA methylation, … omit altered imprinting, for which
the evidence in prostate cancer is … In advanced stage prostate cancers and metastases, the …

… DNA methylation plays an important role in DNA repair, recombination and replication, as
well as regulation of gene activity. DNA methylation … and metastasis of different cancers has …

… are the most predictive diagnostic methylation biomarkers of prostate cancer. By integrating
… DNA methylation alterations that correlate with biochemical recurrence of the tumor. To …

… metastatic disease [15,16,17]. The aim of the current study was to explore the promoter DNA
methylation … Specific interest was put into analyzing promoter methylation levels in relation …

… Methylation signatures specific to an individual’s cancer. We were next interested in plasma
DNA methylation changes that could potentially identify distinct methylation subtypes. The …

… through normal, benign, tumour and metastasis samples. Reflecting their origins, the prostate
cancer cell lines are more alike the metastasis samples than they are the primary tumour …