1 天前 - METHODS cfDNA was extracted from CSF liquid biopsies and analyzed using a
novel methylation-based platform that integrates copy number, tumor classification, and …

1 天前 - … histology, DNA methylation profiling and whole transcriptome analysis (RNA
sequencing), with whole exome or panel DNA sequencing in a subset of cases, revealing a driver …

1 天前 - … of WGBS are limited in that they average/smooth methylation data and fail to capture
… analysis that captures the variability of DNA methylation reads to characterize methylation …

1 天前 - … Our comparative analyses reveal novel molecular model characteristics and
validate their reliability as human disease models. Our data provide new biological insights into …

1 天前 - … Immunofluorescence analysis using confocal high-content microscopy imaging
revealed that … NGS panel, we are running DNA methylation arrays and copy number variations. …

1 天前 - … Analysis of differential chromatin states across MB subgroups using a Hidden Markov
Model revealed a … Integrative bioinformatics coupled with CUT&RUN analysis revealed …

1 天前 - … Methylation analysis revealed no match … DNA extraction in one patient with low
grade glioneuronal spinal cord tumor. Among the 5 tumors with duplicate methylation analyses …

1 天前 - … In summary, we describe a novel type of MB identified by DNA methylation profiling
that likely needs to be addressed separately during the retrospective analyses of MB patient …

1 天前 - … Unsupervised analysis revealed that chromatin compartmentalization is subgroup
stratified. Gene loci contained in subgroup-unique active compartments correspondingly …

1 天前 - … DNA methylation analyses confirmed the maintenance of molecular identity in
these tumoroids after long-term culture (>5 passages). Transcriptome analyses reveal a more …