DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons

KD Siegmund, CM Connor, M Campan, TI Long… - PloS one, 2007 - journals.plos.org
… Furthermore, we show that DNA methylation is dynamically regulated in differentiated …
Collectively, our results suggest that DNA methylation in the human cerebral cortex, including its …

DNA methylation signatures in development and aging of the human prefrontal cortex

S Numata, T Ye, TM Hyde, X Guitart-Navarro… - … Journal of Human …, 2012 - cell.com
DNA methylation is strongly associated with genotypic variants … in brain development and
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human

[HTML][HTML] DNA methylation signatures within the human brain

C Ladd-Acosta, J Pevsner, S Sabunciyan… - … Journal of Human …, 2007 - cell.com
… analyzed 76 brain samples representing cerebral cortex (n=35)… change in DNA methylation
(P<.004)—among brain regions. … that DNA methylation signatures distinguish brain regions …

Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders

T Kato, K Iwamoto - Neuropharmacology, 2014 - Elsevier
… analysis of DNA methylation and hydroxymethylation in the human brain are summarized.
A … between the cerebral cortex and cerebellum were confirmed in an independent cohort. …

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

AE Jaffe, Y Gao, A Deep-Soboslay, R Tao… - Nature …, 2016 - nature.com
… In conclusion, the epigenetic landscape represented by DNA methylation in the human brain
varies markedly across development. Genetic loci implicated in risk for schizophrenia and …

Substantial DNA methylation differences between two major neuronal subtypes in human brain

A Kozlenkov, M Wang, P Roussos… - Nucleic acids …, 2016 - academic.oup.com
… cell identity in the brain. To elucidate the role of DNA methylation in neuronal differentiation,
… the two major populations of human prefrontal cortex neurons—GABAergic interneurons …

Distinct DNA methylation changes highly correlated with chronological age in the human brain

DG Hernandez, MA Nalls, JR Gibbs… - Human molecular …, 2011 - academic.oup.com
… age and DNA methylation level. Lastly, we show that the CpG sites where the DNA methylation
level is significantly associated with age are physically close to genes involved in DNA

DNA methylation and its basic function

LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
… cells develop a stable and unique DNA methylation pattern that regulates tissue-… of
DNA methylation and demethylation in the nervous system. We will describe the DNA (de)methylation

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

JV Sanchez-Mut, E Aso, N Panayotis, I Lott, M Dierssen… - Brain, 2013 - academic.oup.com
DNA methylomes obtained from the cerebral cortex were used to identify aberrant DNA
methylation … comparison of the DNA methylation patterns in cerebral cortex and the rest of the …

Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices

Y Xin, B Chanrion, MM Liu, H Galfalvy, R Costa… - PloS one, 2010 - journals.plos.org
… observe in DNA methylation in cerebellum and regions of the cerebral cortex may contribute
to … Our findings showing divergence of DNA methylation profiles in regions of cerebral cortex