3 天前 - … Finally, I explore the role of the epigenome in germline development and disease
by defining differential 5mC in oocytes from a mouse model of polycystic ovary syndrome, a …

8 天前 - … It is characterized by an autosomal dominant inheritance pattern and is primarily
caused by germline DNA mutations in the mismatch repair (MMR) genes. The MMR system …

9 天前 - … numbers with germline mutations were relatively small (five cases), there was no
significant difference of PAX2 expression between EECs with somatic or germline mutations of …

12 天前 - … Methylation Analysis Kit (MspI/ HpaII) instructions were followed in determining
the DNA methylation … The present study of BC patients identified seven inherited germline …

12 天前 - … germline DNA methylation levels between the treated and untreated lineages and
across generations. While stable global DNA methylation … in sperm DNA methylation that are …

21 天前 - … editing, RNA editing, DNA methylation editing, priming editing… GATK HaplotypeCaller,
a tool for evaluating germline … To destruct the RNA editing activities without affecting DNA …

33 天前 - … of cell cycle control via the methylation of tumor suppressor gene promoters, …
germline predisposition patterns and a profile of somatic mutations. Additionally, DNA methylation …

34 天前 - … Furthermore, based on DNA methylation calls, we classify the cellular 34 origin of
reads to either somatic or germline cells in the testis tissue. We identify 1692 35 crossovers …

40 天前 - … of DNA-methylation analysis in the classification of CNS embryonal tumors and the
importance of investigating somatic and germline … revealed by the DNA methylation study is …

41 天前 - … Germline BRCA1 mutation and/or prolonged or higher exposure to the hormone …
Further DNA methylation analysis will determine epigenetic signatures in both the tissue at risk …