过去一年中添加的文章，按日期排序

EPEN-01. DISTINCT RELAPSE PATTERN ACROSS MOLECULAR EPENDYMOMA TYPES

D Obrecht-Sturm, M Schoof, A Eckhardt… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … Northern American cohorts and correlated DNA methylation patterns and copy-number …
frequently when harboring an alternative fusion or CDNK2A loss (p<0.01, respectively). …
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ETMR-11. RECURRENT GENETIC ALTERATIONS IN EPIGENETICALLY DEFINED PINEOBLASTOMA SUBTYPES

T Goschzik, M Yuan, E Pfaff, M Mynarek… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … of PBL confirmed by reference neuropathology and methylation-based subtyping
were analyzed by … 14 loss (n=21). DICER1 mutations were significantly associated with chr. 14 …
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DIPG-58. TARGETING DISORDERED DNA METHYLATION IN DIPG TO CONSTRAIN VARIABILITY AND INDUCE IMMUNE SIGNALING

AR Tetens, AM Martin, A Arnold, OV Novak… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … The known downstream consequences of this mutation include loss of
repressive chromatin marks, global DNA hypomethylation, and altered gene expression. …
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MDB-63. AN INTERNATIONAL META-ANALYSIS OF SHH MEDULLOBLASTOMA SUBTYPES DEFINES A CLINICALLY SIGNIFICANT HIGH-RISK VARIANT OF SHH …

EC Schwalbe, M Sill, H Suzuki, F Charron… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … SHH subgroups through analysis of MB SHH with DNA-methylation profiling. … loss,
and had dismal survival. The remaining SHH-3A/B subtypes were characterized by 9q loss, …
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METB-07. FREQUENCY AND OUTCOMES OF CDKN2A/B LOSS IN PEDIATRIC GLIOMA

PC Power, J Jones, SN Chi, L Baird, KP Fehnel… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … Central pathology review and methylation … /B loss is identified in a subset of both
pediatric low- and high-grade gliomas. Our data suggest that homozygous CDKN2A/B loss in …
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EPEN-12. EZHIP IMPACTS CELLULAR DIFFERENTIATION IN POSTERIOR FOSSA GROUP A EPENDYMOMA

C Jaunecker, A Jenseit, T Zehetbauer, N Stepien… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … expression, 1q-gain/6q-loss, DNA methylation subtype). Impact on mRNA levels
of … and investigate DNA methylation, histone marks and EZHIP binding at these gene loci. …
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DIPG-87. TARGETING GENE-REPRESSIVE EPIGENETIC REGULATION TO INDUCE INTERFERON SIGNALING IN DIFFUSE MIDLINE GLIOMA

J Craig-Schwartz, AR Tetens, K Lunsford… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … to loss of gene-repressive H3K27me3 marks, global DNA … DIPG cells retain histone
methylation at histone H3 lysine … of DNA methylation and histone H3K9 methylation elicits …
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HGG-50. LOW GRADE GLIOMA CAUGHT IN TRANSFORMATION: UTILITY OF COMPREHENSIVE GENOMIC PROFILING IN PEDIATRIC LI FRAUMENI SYNDROME …

S Nagabushan, N Fuentes-Bolanos, LMS Lau… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … no DNA methylation match, (v11b4 and 12.5), but loss of … chromosome 17 loss);
single copy chromosome X loss with … -grade astrocytoma except for mosaic loss of H3K27me3. …
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HGG-27. IDH-AND H3-WILDTYPE HIGH-GRADE GLIOMAS OCCURRING IN TEENAGERS AND YOUNG ADULT PATIENTS COMPRISE NOVEL MOLECULAR …

R Pereira, A Mackay, Y Grabovska, A Clarke… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … DNA methylation profiling (Illumina EPIC BeadArrays, … using publicly available
methylation and sequencing data … fewer chr7 gains and chr10 losses, and more CDKN2A/B …
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EPEN-08. MULTI-OMICS PROFILES REVEAL UNIQUE DEFINING MOLECULAR FEATURES OF POSTERIOR FOSSA EPENDYMOMA SUBTYPE A FROM INFANTS

A Lourdusamy, RJ Chapman, TA Ritzmann… - Neuro …, 2024 - ncbi.nlm.nih.gov
1 天前 - … profiles derived from DNA methylation arrays showed that … or losses were detected,
however, copy number loss … , while 1q gain, 6q loss, and 22q loss were more frequent in …
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