Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
… The study revealed that one half of the loci where DNA methylation and age, which are
associated in a naïve model, can be responsible for the factors affecting demographic features …

Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex

KM Bakulski, DC Dolinoy, MA Sartor… - … of Alzheimer's …, 2012 - content.iospress.com
… The correlation between DNA methylation and gene expression in our study support the
cell line and mouse model findings. The Illumina HumanMethylation27 BeadArray platform …

Prediction of Alzheimer's disease based on deep neural network by integrating gene expression and DNA methylation dataset

C Park, J Ha, S Park - Expert Systems with Applications, 2020 - Elsevier
… We present a novel Alzheimer's disease prediction model based on deep neural network. …
based model that can predict AD using large-scale gene expression and DNA methylation data…

[HTML][HTML] Utility of DNA Methylation as a Biomarker in Aging and Alzheimer's Disease

L Milicic, T Porter, M Vacher… - … of Alzheimer's Disease …, 2023 - content.iospress.com
… As outlined above, and summarized in Table 1, DNAm clocks have been developed using
several different training models and as such reflect different aspects of disease and the aging …

[HTML][HTML] Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data

Y Sun, J Zhu, Y Yang, Z Zhang, H Zhong… - Translational …, 2023 - nature.com
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is critical
to … Herein, in this study, we leveraged two sets of DNA methylation prediction models built …

DNA methylation in repetitive elements and Alzheimer disease

V Bollati, D Galimberti, L Pergoli, E Dalla Valle… - Brain, behavior, and …, 2011 - Elsevier
models adjusting for age and gender. This may be partly explained by the small size of our
population, which provided us with limited statistical power to perform multivariate modeling. …

Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells

A Di Francesco, B Arosio, A Falconi… - Brain, behavior, and …, 2015 - Elsevier
Alzheimer’s disease (AD). In this study we measured genome-wide DNA methylation by
luminometric methylation … of genome-wide DNA methylation, on DNA isolated from peripheral …

[HTML][HTML] Distinct sex-specific DNA methylation differences in Alzheimer's disease

T C. Silva, W Zhang, JI Young, L Gomez… - Alzheimer's research & …, 2022 - Springer
… Overall, our results show that the DNA methylation … Our best-performing sex-specific
methylation-based prediction model in … with our methylation-based prediction models

DNA methylation and Alzheimer's disease

T van Groen - Epigenetics of aging, 2010 - Springer
… This model operates on the regulatory region (promoter) of … Alzheimer’s disease; the
decreased DNA methylation status … plays a role through the nutritional status of the individual, ie, …

DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health

J Mur, DL McCartney, RM Walker… - Alzheimer's & …, 2020 - Wiley Online Library
… We assessed blood-based DNA methylation at 13 CpGs in the … Using linear mixed models
regression, we examined the … risks of Alzheimer's disease (AD) and cardiovascular disease. …