[HTML][HTML] An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene
… differences in either MCI or AD relative to CTL using an ANOVA model after adjusting for
the covariates of age, sex, cell proportions, and batch (Supplementary Table 1). No DMPs …
the covariates of age, sex, cell proportions, and batch (Supplementary Table 1). No DMPs …
[HTML][HTML] DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
… To calculate the association between DNA methylation and Braak stage progression or
aging, we applied multiple linear regression models thereby correcting for sex, age and batch …
aging, we applied multiple linear regression models thereby correcting for sex, age and batch …
Mathematical models of DNA methylation dynamics: Implications for health and ageing
L Zagkos, M Mc Auley, J Roberts… - Journal of theoretical …, 2019 - Elsevier
… previous mathematical models. In addition, our nonlinear model predicts DNA methylation
promoter … The findings from our models have implications for our current understanding of how …
promoter … The findings from our models have implications for our current understanding of how …
[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
… DNA methylation in four major neurodegenerative diseases: Alzheimer's disease (AD),
Parkinson's disease (… Using the AD model cell line H4-sw, which harbors the Swedish mutation …
Parkinson's disease (… Using the AD model cell line H4-sw, which harbors the Swedish mutation …
[HTML][HTML] DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer's, related tauopathies and genetic tauopathies
G Zimmer-Bensch, H Zempel - Cells, 2021 - mdpi.com
… expression of genes involved in DNA repair, ia BRCA1, in a mouse model of AD [128]. …
vitro and in vivo mouse models, acting neuroprotectively against Aβ-induced DNA double-strand …
vitro and in vivo mouse models, acting neuroprotectively against Aβ-induced DNA double-strand …
Research progress in predicting DNA methylation modifications and the relation with human diseases
C Ao, L Gao, L Yu - Current Medicinal Chemistry, 2022 - ingentaconnect.com
… and are excellent algorithms for building prediction models. In addition, in recent years, …
diseases related to DNA methylation modification, including hypertension, Alzheimer's disease …
diseases related to DNA methylation modification, including hypertension, Alzheimer's disease …
Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals
P Tannorella, A Stoccoro, G Tognoni, L Petrozzi… - Neuroscience …, 2015 - Elsevier
… We studied DNA methylation levels of six candidate AD … cell cultures or with animal models
of AD revealed that … involved in APP processing or DNA methylation reactions able to induce …
of AD revealed that … involved in APP processing or DNA methylation reactions able to induce …
Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer's disease
CE Humphries, MA Kohli, L Nathanson… - … of Alzheimer's …, 2015 - content.iospress.com
… DNA methylation were located throughout the genome and substantial changes in methylation
… DNA methylation had reduced influence on transcription within LOAD in the myelination …
… DNA methylation had reduced influence on transcription within LOAD in the myelination …
[HTML][HTML] The role of DNA methylation and histone modifications in neurodegenerative diseases: a systematic review
… and memory in a mouse model of Alzheimer's disease. Those findings provide support that
… Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear …
… Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear …
[HTML][HTML] Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
…, Alzheimer's Disease Neuroimaging Initiative… - Genome biology, 2021 - Springer
… shared DNA methylation alterations across brain disorders. … , and normalization of DNA
methylation data conducted in each … methylated positions (DMPs), we applied mixed-linear model…
methylation data conducted in each … methylated positions (DMPs), we applied mixed-linear model…