Brain DNA methylation patterns in CLDN5 associated with cognitive decline
… All association models were adjusted for age at death, … -wide association between brain
tissue–based DNA methylation in … This association was significant across different domains and …
tissue–based DNA methylation in … This association was significant across different domains and …
Glia-specific APOE epigenetic changes in the Alzheimer's disease brain
J Tulloch, L Leong, Z Thomson, S Chen, EG Lee… - Brain research, 2018 - Elsevier
… Alzheimer’s disease (AD). Our recent identification of altered APOE DNA methylation in AD
… In our second model, we compared overall percentages by disease status by including fixed …
… In our second model, we compared overall percentages by disease status by including fixed …
The role of methylated circulating nucleic acids as a potential biomarker in Alzheimer's disease
… specific transcription and methylation [14]. These findings supported the notion that DNA
methylation is a … Two different AD mouse models were used in this study. The acute Aβ-induced …
methylation is a … Two different AD mouse models were used in this study. The acute Aβ-induced …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
… DNA methylation-based age prediction models are not only … DNA methylation levels
were also observed in the peripheral blood mononuclear cells of late onset Alzheimer disease …
were also observed in the peripheral blood mononuclear cells of late onset Alzheimer disease …
Role of epigenetics in Alzheimer's and Parkinson's disease
JBJ Kwok - Epigenomics, 2010 - Taylor & Francis
… transgenic animal models suggests … as DNA methylation at CpG dinucleotides or oxidation
of guanosine residues Citation[42]. DNA methylation can perturb the interaction of methylated …
of guanosine residues Citation[42]. DNA methylation can perturb the interaction of methylated …
Abnormal homocysteine metabolism: an insight of Alzheimer's disease from DNA methylation
T Pi, B Liu, J Shi - Behavioural Neurology, 2020 - Wiley Online Library
… DNA methylation pathway with a series of changes in AD-related substance. This review will
concentrate on the relation between DNA methylation … transgenic mouse model shows that …
concentrate on the relation between DNA methylation … transgenic mouse model shows that …
[HTML][HTML] Altered DNA methylome profiles of blood leukocytes in Chinese patients with mild cognitive impairment and Alzheimer's disease
S Wu, F Yang, S Chao, B Wang, W Wang, H Li… - Frontiers in …, 2023 - frontiersin.org
… : DNA methylation plays a potential role in the pathogenesis of Alzheimer’s disease (AD). …
be carried out in vitro and in animal models to provide stronger evidence to support differential …
be carried out in vitro and in animal models to provide stronger evidence to support differential …
The APOE gene is differentially methylated in Alzheimer's disease
J Foraker, SP Millard, L Leong… - … of Alzheimer's …, 2015 - content.iospress.com
… DNA methylation. Thus, we hypothesize that the presence of an ɛ4 allele changes the DNA
methylation … a second linear mixed effects model (Model 2) that expanded Model 1 with the …
methylation … a second linear mixed effects model (Model 2) that expanded Model 1 with the …
Applying Epigenetics to Alzheimer's Disease via the Latent Early–life Associated Regulation (LEARn) Model
… DNA methylation was found to be reduced in the brain entorhinal cortex layer II of AD … ,
and it is such induced DNA methylation variations that lie at the core of the LEARn model. …
and it is such induced DNA methylation variations that lie at the core of the LEARn model. …
[HTML][HTML] Understanding epigenetics in the neurodegeneration of Alzheimer's disease: SAMP8 mouse model
C Griñán-Ferré, R Corpas… - … of Alzheimer's …, 2018 - content.iospress.com
… DNA methylation has been considered a normal mechanism of gene silencing with a crucial
role in the transcriptional repression of repeated and centromeric regions. However, the …
role in the transcriptional repression of repeated and centromeric regions. However, the …