… the DNA repair pathways [6–9]. Here, we briefly review the current information on DNA repair
… We highlight the main features of the major DNA repair pathways and report the presence …

… cruzi biology, these studies are highly relevant since oxidative stress pathways are part of …
By unveiling new peculiar aspects of T. cruzi biology, emerging data on DNA repair pathways …

… -mediated DNA repair increased resistance to BZ, … DNA repair proteins increase parasite
survival upon BZ exposure, indicating that the drug induces lesions in the mitochondrial DNA …

… Thus, it is paramount for the parasite to count on an efficient DNA repair machinery to …
the conserved and peculiar DNA repair mechanisms described in T. cruzi against oxidative …

… cruzi. We establish that ROS/RNS generate nuclear and kinetoplastid DNA damage in T.
cruzi that may be partially repaired by the parasite. Furthermore, we determined that both …

… displays many strategies to overcome ROS, with unique antioxidant enzymes and co-factors
(such as, tryparedoxin peroxidase, TcSOD and trypanothione) and efficient DNA repair …

… major was able to promote DNA repair and growth recovery in the presence of MMS. ASF1c
… the efficiency of DNA repair in either of the parasites but did accentuate the DNA damage …

… Trypanosoma cruzi is the causative agent of Chagas disease, a tropical neglected illness …
Our research group focuses on the elucidation of DNA repair and metabolism of T. cruzi, and …

… by host cells and Trypanosoma cruzi, focusing on the DNA repair mechanisms of these
organisms throughout infection including the relationship between DNA damage, stress …

… The complete genomic sequences of Leishmania major (20), Trypanosoma brucei (21), and
Trypanosoma cruzi (22), known as the tritryps genomes, became available in 2005. In these …