Investigations into intracellular replication and differentiation of Trypanosoma cruzi within the
mammalian host have been restricted by limitations in our ability to detect parasitized cells …

… DNA metabolism in trypanosomatids have been very limited. Together with recent experimental
studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi… of the DNA …

… Previously, we have shown that in Trypanosoma cruzi, an early-divergent eukaryote, DNA
… Based on these findings, we propose that DNA replication in T. cruzi is accomplished by the …

… After the incision, exonuclease 1 (EXO1) removes the damaged site, while DNA polymerase
and DNA ligase I fill and close the gaps, respectively [55]. TcMSH2 was the first MMR …

… In the kDNA of untreated trypanosomes, only very few replicating molecules can be
detected. If we consider that the speed of DNA replication of E. coli is 25 sm/min (29) and that of …

… DNA repair pathways from Trypanosoma cruzi are believed to protect genomic DNA and
kinetoplast DNA (… can lead to cytotoxic base transversions during DNA replication. In mammals, …

… We used this TcPolκ-overexpressing lineage to test whether this DNA polymerase could
also increase T. cruzi resistance to BZ. As observed for TcPolη, TcPolκ overexpression …

… infected by Trypanosoma cruzi, etiologic agent of Chagas disease, although its role in host
cell DNA/RNA metabolism has not been fully described. In this study, we investigated how T. …

… DNA polymerase kappa (Polκ) is a low-fidelity polymerase … subfamily of Y-family DNA
polymerases, has remained elusive… of Polκ from the protozoan Trypanosoma cruzi (TcPolκ). The …

… Because we found two orthologs of Polθ in T. cruzi, one containing the DNA polymerase …
other containing the helicase domain, we asked whether Polθ could interact with ORC in T. …