… The accumulation of DNA in the cytoplasm can initiate the … Moreover, cytosolic DNA sensing
is intimately connected to … the molecular mechanisms whereby cytosolic DNA enables cell-…

… Accordingly, loss of STING or cGAS in tumor cells decreases tumor infiltration of T cells and
… We conclude that DNA sensing within tumor cells is essential for dMMR-triggered anti-tumor …

… cell-derived factors can facilitate induction of antitumor immunity that contributes to tumor
control with conventional cancer therapeutics. However, in the context of a spontaneous …

… sensing following radiotherapy is dominated by the cGAS-STING-dependent cytosolic DNA
sensing … However, tumor control by radiation was unaffected by anti-HMGB-1 treatment (…

… Contrary to the classic role of DCs in IR-tumor control, these cells may concurrently adopt
protumorigenic behaviors. An intricate balance between STING-dependent canonical and …

… early sensors of DNA damage, specifically the protein ATM and the enzyme DNA-dependent
protein kinase (DNA… effects against DNA damage. As shown in the case of cells treated with …

… to optimize tumor control. In this study, Deng et al. demonstrate a novel mechanism that
the cytosolic DNA sensing for type I IFN is induced via radiation treatment for tumor control. In …

… (D) RNASEH1 (RNH)- or control-transduced … DNA accumulates in tumor cells and activates
the cGAS/STING pathway. Recognition of cytosolic DNA by this intracellular DNA sensor …

… tumor-specific CTLs leading to effective tumor control. As mentioned previously, over 10 DNA
sensor … In addition to TLR9-mediated tumor DNA sensing, we have previously found that …

… We report that p53 promotes the degradation of the DNA exonuclease TREX1, resulting
in … DNA accumulation resulting from TREX1 degradation activates the cytosolic DNA-sensing …