Spectroscopy and molecular docking analysis reveal structural specificity of flavonoids in the inhibition of α-glucosidase activity

J Liu, Y Kong, J Miao, X Mei, S Wu, Y Yan… - International journal of …, 2020 - Elsevier
… The human α-glucosidase (C-terminal maltase-glucoamylase, GH31) was used in the …
docking analysis to determine the interaction of eriocitrin and eriodictyol with the α-glucosidase. …

Exploring the structure–activity relationship and interaction mechanism of flavonoids and α-glucosidase based on experimental analysis and molecular docking …

H Tang, L Huang, C Sun, D Zhao - Food & function, 2020 - pubs.rsc.org
α-Glucosidase (AG) has always been an indispensable drug target for the treatment of type
2 diabetes. Herein, an integrated method consisting of enzyme kinetics, multi-spectroscopy …

Inhibition of α-glucosidase by trilobatin and its mechanism: kinetics, interaction mechanism and molecular docking

M He, Y Zhai, Y Zhang, S Xu, S Yu, Y Wei, H Xiao… - Food & Function, 2022 - pubs.rsc.org
analysis in this study. The interaction mechanism between trilobatin and α-glucosidase in …
FT–IR as well as molecular docking analysis. This study probably expands new understanding …

Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking

L Han, C Fang, R Zhu, Q Peng, D Li, M Wang - International Journal of …, 2017 - Elsevier
… In this study, multispectroscopic techniques and molecular docking analysis were used to …
on α-glucosidase. The results showed that phloretin reversibly inhibited α-glucosidase in a …

α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking

J Yan, G Zhang, J Pan, Y Wang - International journal of biological …, 2014 - Elsevier
… (B) Cluster analysis of the AutoDock docking runs of luteolin with α-glucosidase. (For
interpretation of the references to color in this text, the reader is referred to the web version of the …

Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation

T Dai, J Chen, DJ McClements, T Li, C Liu - International journal of …, 2019 - Elsevier
… and α-glucosidase is poorly understood. In this study, spectroscopic analyses and computer
simulations were used to investigate the interactions between α-glucosidase and B-type …

Inhibitory kinetics and mechanism of rifampicin on α-glucosidase: Insights from spectroscopic and molecular docking analyses

MZ Lin, WM Chai, YL Zheng, Q Huang… - International journal of …, 2019 - Elsevier
… on α-glucosidase were investigated by multispectroscopic methods along with molecular
docking technique. The results showed that rifampicin inhibited α-glucosidase activity …

Inhibitory mechanism of sinensetin on α-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses

D Liu, X Cao, Y Kong, T Mu, J Liu - International Journal of Biological …, 2021 - Elsevier
α-glucosidase and non-enzymatic glycation was explored with multi-spectroscopic techniques
and molecular docking analysis … between sinensetin and α-glucosidase were studied. …

α-Glucosidase Inhibitors from Brickellia cavanillesii

S Escandón-Rivera, M González-Andrade… - Journal of natural …, 2012 - ACS Publications
Docking analysis predicted … α-glucosidase, a molecular docking study was next performed
using the program AutoDock4. (31, 32) After geometric optimization, the ligands were docked

Phytochemical Analysis, αGlucosidase and Amylase Inhibitory, and Molecular Docking Studies on Persicaria hydropiper L. Leaves Essential Oils

MH Mahnashi, YS Alqahtani, BA Alyami… - Evidence‐Based …, 2022 - Wiley Online Library
… acarbose are the only three α-glucosidase inhibitors which are in … analyses the essential
oils against two important targets of the type-2 diabetes, α-glucosidase and α-amylase and dock