Usefulness of a dopamine transporter PET ligand [18F] β-CFT in assessing disability in Parkinson's disease

JO Rinne, H Ruottinen, J Bergman… - Journal of Neurology …, 1999 - jnnp.bmj.com
… Our results show that striatal dopamine transporter uptake declines with increasing disability
in Parkinson's disease. Thus, [ 18 F]β-CFT is a useful ligand, not only in the diagnosis of …

Dopamine transporter binding in rat striatum: a comparison of [O-methyl-11C] β-CFT and [N-methyl-11C] β-CFT

KK Yoder, GD Hutchins, BH Mock, X Fei… - Nuclear medicine and …, 2009 - Elsevier
… in vivo density of monoamine transporters, including the dopamine transporter (DAT). [ 11
C]β-CFT is useful for studying DAT as a marker of dopaminergic innervation in animal models …

The functional domains of dopamine transporter for cocaine analog, CFT binding

SH Lee, MY Chang, DJ Jeon, DY Oh, H Son… - … & Molecular Medicine, 2002 - nature.com
Dopaminergic neurotransmission is terminated by the activity of the presynaptic dopamine
transporter (DAT) that mediates the reuptake of extracellular dopamine (DA) into the cell, and …

Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease

H Li, X Zhang, J Zhang - Int J Radiat Med Nucl Med, 2016 - ijrmnm.com
CFT binding to the striatal dopamine transporters in the Fischer 344 rats: a PET study[J]. Ann
Dopamine transporter imaging agent 11C鄄CFT and 18F鄄CFT and its clinical application …

Progression in Parkinson's disease: A positron emission tomography study with a dopamine transporter ligand [18F]CFT

E Nurmi, HM Ruottinen, V Kaasinen… - Annals of Neurology …, 2000 - Wiley Online Library
… No studies have previously been performed on dopamine transporter ligand … dopamine
transporter function with PET during the progression of PD using [18F]CFT18,19 dopamine

Striatal uptake of the dopamine reuptake ligand [11C]β-CFT is reduced in Alzheimer's disease assessed by positron emission tomography

JO Rinne, N Sahlberg, H Ruottinen, K Nagren… - Neurology, 1998 - AAN Enterprises
… However, the messenger RNA for the dopamine transporter in … C]β-CFT uptake is not entirely
due to loss of nigral neurons. … of the dopamine reuptake ligand, [ 11 C]β-CFT, declines in …

Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson's Disease: A CFT and RAC PET Study

M Mishina, K Ishii, M Suzuki… - The Neuroradiology …, 2011 - journals.sagepub.com
… of dopaminergic system in the striatum of the patients with PD at different stages using CFT,
Dopaminergic function and dopamine transporter binding assessed with positron emission …

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter

RE Whitehead, JV Ferrer, JA Javitch… - Journal of …, 2001 - Wiley Online Library
… Reactivity of DAQ with Cys 90 increased the affinity of [ 3 H]β-CFT for the transporter, …
dopamine transporter (hDAT), using both wild-type and cysteine mutant constructs of this transporter

Reproducibility and Effect of Levodopa on Dopamine Transporter Function Measurements: A [18F]CFT PET Study

E Nurmi, J Bergman, O Eskola, O Solin… - Journal of Cerebral …, 2000 - journals.sagepub.com
… With [ 123 I]β-CIT SPECT, no significant difference among … of a dopamine transporter
PET ligand, [ 18 F]CFT, in … F]CFT uptake and the normal variation of test–retest [ 18 F]CFT

… in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: Compartment analysis for βCFT …

Y Ouchi, E Yoshikawa, H Okada… - Annals of Neurology …, 1999 - Wiley Online Library
… -CFT binding in the striatum in the present study is in accord with previous reports of dopamine
transporter … Specifically, the putaminal reduction in the -CFT binding was more prominent …