过去一年中添加的文章,按日期排序

X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model

J Mou, XL Ning, XY Wang, SY Hou… - Journal of Medicinal …, 2024 - ACS Publications
2 天前 - … in the number of TH-positive dopamine neurons and TH density within the …
dopamine (Figure 8a), indicating that 43 has the activity to protect against the loss of dopaminergic

NPT100-18A rescues mitochondrial oxidative stress and neuronal loss in human iPSC-based Parkinson's model

JE Alecu, V Sigutova, RM Brazdis, S Lörentz… - 2024 - researchsquare.com
2 天前 - … could prevent loss of human dopaminergic neurons in vitro, … of dopaminergic neurons
in a human in vitro model of PD. … model of familial Parkinson's disease. Human molecular …

Expression of metabolic genes associated with changes in brain structure across the lifespan affects patients (pts) outcomes in metastatic colorectal cancer (mCRC) …

F Battaglin, J Millstein, Y Yang, S Soni, S Algaze… - 2024 - ascopubs.org
4 天前 - … We previously showed that genetic variants in dopamine and Parkinson’s disease
genes are predictive and prognostic in mCRC. Indeed, the brain-gut axis is emerging as a …

Network pharmacology and molecular docking approach to unveil the mechanism of amantadine for Parkinson's disease

N Bhardwaj, H Tyagi, S Gupta… - Advances in AI for …, 2024 - books.google.com
8 天前 - … that is a prompt symptom of Parkinson's disease. Amantadine is a drug which is
used as a dopamine facilitator (increases the availability of dopamine in nerve endings) with …

[HTML][HTML] Evaluation of the Parkinson's Remote Interactive Monitoring System in a Clinical Setting: Usability Study

B Bridges, J Taylor, JT Weber - JMIR Human Factors, 2024 - humanfactors.jmir.org
9 天前 - … disorder is Parkinson disease (PD), a progressive neurodegenerative … dopamine
levels, and other dopaminergic agonists. As the disease advances, the efficacy of the drug

Lixisenatide in early parkinson's disease: efficacy, safety, and future directions: a correspondence

H Irfan, SU Muneer, AB Maheshwari, N Kumar… - Neurosurgical …, 2024 - Springer
9 天前 - … , particularly Levodopa that supplements the missing dopamine and makes movements
dopamine agonists, which act like dopamine and can be given alone or with Dopamine

The effect of anticholinergic drugs on cognition of patients with Parkinson's disease: a cohort study from the Egyptian population

SA Hamed, AFE Hadad - Expert Review of Clinical Pharmacology, 2024 - Taylor & Francis
10 天前 - … In this study, benztropine mesylate (cogintol), an anticholinergic drug, was prescribed
… amantadine sulfate (PK-merz), a dopaminergic drug in a maintenance dose of 200 mg/…

[PDF][PDF] 3D Neuronal Monitoring Platforms for Electrochemical Sensing Of Neurotransmitters

N Pascual, N Alegret, A Silvestri, FJ Gil-Bea, M Prato - avestia.com
12 天前 - … and detect dopamine release of the iPSC derived dopaminergic neurons through
… recaptaton of dopamine was added to confirm the increase of dopamine of the neurons. …

… OF AEROBIC EXERCISE AND FOOD RESTRICTION ON DOPAMINERGIC NEURONS AND CATALEPSY IN THE BRAIN TISSUE OF PARKINSON'S DISEASE RATS

R Pozesh Jadidi - Feyz Medical Sciences Journal - feyz.kaums.ac.ir
14 天前 - … Background: Parkinson's disease is one of the most common disorders of the nervous
… catalepsy and dopaminergic neurons plays a role in managing Parkinson's disease. This …

IRL790 modulated striatal D1 neurons synaptic plasticity ameliorating Levodopa-induced dyskinesia in mouse

X Wang, W Zhang - Frontiers in Aging Neuroscience - frontiersin.org
15 天前 - … treatment for Parkinson's disease (PD). Nevertheless, prolonged use of this drug
may … Within the striatum, the amount of Dopamine D3 receptor(D3R) is notably increased in …