Long-term results of the MD Anderson randomized dose-escalation trial for prostate cancer

DA Kuban, SL Tucker, L Dong, G Starkschall… - International Journal of …, 2008 - Elsevier
… trial was opened at The University of Texas MD Anderson Cancer Center in 1993. This was
doses for prostate cancer. Previously reported results of this study supported dose escalation

Hazards of dose escalation in prostate cancer radiotherapy

D Kuban, A Pollack, E Huang, L Levy, L Dong… - International Journal of …, 2003 - Elsevier
… of prostate cancer, the current prevailing hypothesis centers on delivering higher doses to the
… by increasing the radiation dose in the intermediate-risk group of prostate cancer patients, …

Phase I dose-escalation study of stereotactic body radiation therapy for low-and intermediate-risk prostate cancer

TP Boike, Y Lotan, LC Cho, J Brindle… - Journal of clinical …, 2011 - ascopubs.org
… In conclusion, dose escalation on this multi-institutional phase I trial focusing on acute
toxicity (< 90 days from completion of therapy) in patients with localized prostate cancer was …

Dose escalation for prostate adenocarcinoma: a long-term update on the outcomes of a phase 3, single institution randomized clinical trial

D Pasalic, DA Kuban, PK Allen, C Tang… - International Journal of …, 2019 - Elsevier
prostate adenocarcinoma and its propensity for late biochemical or clinical failures, the true
benefit, if any, of radiation dose escalation … the value of dose escalation for prostate cancer. …

Optimization of conformal radiation treatment of prostate cancer: report of a dose escalation study

GE Hanks, TE Schultheiss, AL Hanlon, M Hunt… - International Journal of …, 1997 - Elsevier
… the value of dose escalation in optimizing the radiation treatment of prostate cancer. Methods
Dose was escalated from 68 Gy to 79 Gy. Patient status is reported at 3 years follow-up, …

Long-term failure patterns and survival in a randomized dose-escalation trial for prostate cancer. Who dies of disease?

DA Kuban, LB Levy, MR Cheung, AK Lee… - International Journal of …, 2011 - Elsevier
… study dose escalation for patients with PSA >10 ng/mL or high-risk disease was shown to
provide significant benefit in biochemical and clinical outcome as well as in prostate cancer–…

What is the ideal radiotherapy dose to treat prostate cancer? A meta-analysis of biologically equivalent dose escalation

NG Zaorsky, JD Palmer, MD Hurwitz, SW Keith… - Radiotherapy and …, 2015 - Elsevier
… This study suggests that prostate cancer control with dose escalation with RT follows a
sigmoidal dose–response curve. An increase in BED to 200 Gy (at α/β of 1.5) was associated with …

Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer

MJ Zelefsky, SA Leibel, PB Gaudin, GJ Kutcher… - International Journal of …, 1998 - Elsevier
… a significant effect of dose escalation on the response of human prostate cancer to irradiation
… evaluate the paradigm of dose escalation in prostate cancer. Dose escalation with 3D-CRT …

Complications from radiotherapy dose escalation in prostate cancer: preliminary results of a randomized trial

MR Storey, A Pollack, G Zagars, L Smith… - International Journal of …, 2000 - Elsevier
… Other studies have shown that dose escalation is possible using conformal techniques …
trials evaluating dose escalation for prostate cancer patients treated in the prostate-specific …

Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer

A Al-Mamgani, WLJ Van Putten… - International Journal of …, 2008 - Elsevier
… In this study, late morbidity after high-dose RT for localized prostate cancer was in line with
the experience from other dose-escalation trials 3, 5, 7, 8. The cumulative incidence of late …