… dose gemcitabine plus docetaxel as second-line therapy, the frequency of thrombocytopenia
was much lower in this study of the regimen as first-line treatment… the second-line study [25]. …

BACKGROUND Gemcitabine infusion at the fixed dose rate of 10 mg/m 2 per minute (FDR‐gemcitabine)
has pharmacokinetic advantages and may result in improved therapeutic …

… based on sequential treatment with FOLFIRI.3 and fixed-dose rate gemcitabine. … -dose rate
gemcitabine, by comparison with fixed-dose rate gemcitabine alone, as the first-line treatment …

… combination showed that the 5-year cardiovascular event rate was lower in the FDC
group compared with loose-dose (HR = 0.74; 95% CI: 0.70–0.77; p < 0.0001)Citation55. …

… After ASCT for responding patients or after salvage therapy for non-responders, whole
brain radiation therapy at a dose of 30 Gy was delivered. The objective response rate to the …

… In conclusion, the split-dose T–PLF regimen is an active treatment with high efficacy in
terms of tumor response rate, TTP and OS. In patients with metastatic disease the considerably …

… High activity was observed at all dose levels, particularly the last four, with a response rate
of 81% (95% confidence interval (95% CI): 62.5-92.5). Median time to progression was 46 …

… -term overall survival (OS) rates with CHOP range between 30% … regimen and dose-intensified
schedules based on the Norton–Simon-hypothesis.9, 10 With the advent of high-dose …

… events (first seizures) using information from a previous dose-… that the ratio of hazard rates
for time to first seizure (50 mg … 108 patients had their first on-treatment seizure and patients …

… rates when HDCT was included in first-line treatment compared with historical survivals
observed with conventional-dose … , patients were selected for a treatment change to HDCT based …