… In our study of three dose ratios of buprenorphine and naloxone, we assessed the ability
of these combinations to attenuate opioid agonist effects. The opiate agonist effects of …

… for this 4:1 dose ratio. Their Þndings are concordant … buprenorphine to naloxone ratios and
doses was not examined (Fudala et al. 1996). In contrast, we examined a range of dose ratios…

… different dose ratios of buprenorphine/naloxone have been investigated to determine the
optimal ratio in a full agonist opioid-dependent population.[35–41] In a key trial, buprenorphine …

… combining buprenorphine with naloxone in a 4:1 ratio have … Low doses of injected
buprenorphine/naloxone have been … of buprenorphine/naloxone combinations over a broad dose …

… Naloxone (alone) in much larger doses is sufficiently well … -dependent persons, but doses
of sublingual naloxone of up to 1–… [9] Naloxone in a ratio of buprenorphine to naloxone of 4 : 1 …

… of buprenorphine and naloxone at a fixed dose ratio of 4:1 has … buprenorphine and naloxone
at a fixed dose ratio of 4:1 (2 mg buprenorphine:0.5 mg naloxone and 8 mg buprenorphine…

… The addition of naloxone does not appear to improve the safety profile of buprenorphine. …
®) was altered to include an opioid antagonist, naloxone (NLX) in a 4:1 ratio (Suboxone®), …

… composed of buprenorphine and naloxone in a fixed 4:1 ratio. The fixed ratio was based on
… In high doses, buprenorphine functions as an opioid antagonist to further limit its analgesic …

… abuse liability of various doses of intravenous Bup and Nx at an ≈4/1 ratio. Specifically, we
… amount of Bup and Nx differed while the ratio remained unchanged. Only the positive control …

… designed to determine appropriate combination dose ratios, clinical efficacy and dosage …
effectiveness of the 4:1 buprenorphine/ naloxone ratio to reduce potential for parenteral abuse. …