… the specific human renin inhibitor remikiren lowered blood pressure to normal values. Double
transgenic mice … We conclude that this double transgenic strain will facilitate simultaneous …

… 2 novel transgenic mouse models containing the human renin (… These mice exhibit a very
narrow tissue-specific expression … the brain RAS in double transgenic mice using the PAC160 …

… To determine whether HREN mRNA was present in brain of double-transgenic mice, we
used reverse transcriptase (RT)–PCR. Brains were collected, specific regions were dissected, …

… transgenic mouse models that separately contain and express the human renin (hRen) and
human … In the present study, we report the generation of a double transgenic mouse model in …

… BP elevation of our dual gene carriers generated by cross-mating separate lines of transgenic
mice carrying either the human renin or human angiotensinogen genes whose expression …

… We conclude that dual production of renin and angiotensinogen in the renal proximal tubule
can result in a systemic increase in arterial pressure. These data support a role for a tissue-…

… human renin cannot cleave mouse or rat angiotensinogen and vice versa. We and others
have developed double transgenic mice … regulated, we generated transgenic mice with 160 kb …

… This study demonstrates that the human renin inhibitor aliskiren can inhibit BP and organ …
Our findings also underscore the utility of the dTGR model for studying human renin inhibitors …

… regulation and function and may become the motor of the second century in renin research.
… of human angiotensinogen in human renin transgenic animals. Animals with short transgene …

… Second, abnormal quantitative expression of transgenes in certain tissues has been
reported even when they exhibit proper qualitative expression28; ie, although the expression of …