Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death

VP Yin, CS Thummel, A Bashirullah - The Journal of Cell Biology, 2007 - rupress.org
… -mediated cell death. Before this time, high levels of DIAP1 block salivary gland cell death, …
apoptosis levels can be critical for regulating cell death during development. It also provides …

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2

N Fehrenbacher, L Bastholm, T Kirkegaard-Sørensen… - Cancer research, 2008 - AACR
cells against the lysosomal cell death pathway. Furthermore, knockdown of either lamp1 or
lamp2 is sufficient to sensitize the cells to siramesine-induced cell death and … up-regulation of …

Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

XX Cao, I Mohuiddin, F Ece, DJ McConkey… - … of respiratory cell and …, 2001 - atsjournals.org
… to apoptotic cell death by both clinical … downregulation. We show that exposure to NaB
leads to differentiation as well as apoptotic cell death in two well-characterized mesothelioma cell

Down-regulation of suppressor of cytokine signaling-3 causes prostate cancer cell death through activation of the extrinsic and intrinsic apoptosis pathways

M Puhr, FR Santer, H Neuwirt, M Susani, JA Nemeth… - Cancer research, 2009 - AACR
… lines but not in the parental LNCaP cell line, which is SOCS-3 negative. In this study, we
show that down-regulation of SOCS-3 leads to an increased cell death in prostate cancer cell

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo

P Lingor, P Koeberle, S Kügler, M Bähr - Brain, 2005 - academic.oup.com
… In this study we selectively target proteins involved in apoptotic cell death in RGC. We …
regulation by injection into the optic nerve stump following axotomy is able to down-regulate the …

Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells

M Grzmil, P Thelen, B Hemmerlein, S Schweyer… - The American journal of …, 2003 - Elsevier
… Furthermore, we demonstrate that down-regulation of BI-1 expression via sequence-specific …
prostate carcinoma cell death. These results indicate an important role for BI-1 in cellular

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

T Yokota, K Sugawara, K Ito, R Takahashi… - Biochemical and …, 2003 - Elsevier
… Here, we examined the effect of down regulation or over-expression of DJ-1 on the cell
death after the oxidative-, ER-stress, apoptotic stimulation, and proteasome inhibition. …

Down-regulation of DIAP1 Triggers a NovelDrosophila Cell Death Pathway Mediated by Dark and DRONC

T Igaki, Y Yamamoto-Goto, N Tokushige… - Journal of Biological …, 2002 - ASBMB
… that down-regulation of DIAP1 is sufficient to induce cell death in Drosophila S2 cells. …
of the cell death induced by the down-regulation of DIAP1. Our findings demonstrate a novel …

Apoptosis: molecular regulation of cell death

AJ Hale, CA Smith, LC Sutherland… - European Journal of …, 1996 - Wiley Online Library
cell death and mammalian apoptosis have emphasised the value of this system as a
model for cell death in mammalian cells, … This would lead to down regulation of pS3-dependent …

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

CM Troy, D Derossi, A Prochiantz… - Journal of …, 1996 - Soc Neuroscience
… -induced cell death Our experiments explored the mechanism by which SOD1 downregulation
leads to apoptotic cell death. Past observations, that antioxidants protect cells from SOD1 …