… of tumour suppressor genes such as p16 INK4A & RB1 leading to a down-regulation of the …
, UHRF1 may be regulated by other tumour suppressor genes such as p53 and p73 products […

Introduction ECRG4/C2ORF40 is a potential tumor suppressor gene (TSG) recently identified
in esophageal carcinoma. Its expression, gene copy number and prognostic value have …

… We hypothesized that the downregulation of these metastasis suppressor genes may
also be crucial in the pathogenesis of malignant pheochromocytoma. Furthermore, altered …

Suppressor of cytokine signaling-3 (SOCS-3) acts as a negative feedback regulator of the
Janus-activated kinase/signal transducers and activators of transcription factors signaling …

Background Hepatocellular carcinoma (HCC) is one of the most common cancers in the
world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene …

… Down-regulation of nuclear PAR-4 protein expression predicted a poor prognosis for breast
cancer patients (OS; P= 0.041, log-rank test). PAR-4 down-regulation also correlates with …

… promoter hypermethylation and downregulation of LHX6 in various cancer types. Due to …
Thus, in lung adenocarcinoma, breast cancer, and cervical cancer, downregulation of LHX6 …

… proteolysis inhibitor, blocked down-regulation of IRS1 and … suppressor of cytokine
signaling (SOCS) 3 and caused ubiquitination of IRS1 and IRS2. HCV core-induced down-regulation …

14-3-3 proteins comprise a family of highly conserved and broadly expressed multifunctional
regulatory proteins that are involved in various cellular processes such as cell cycle …

… downregulated in more than 70% of the 49 primary prostatic cancers from untreated patients.
In 10 such untreated patients, down-regulation … prostatic cancers had downregulation, with …