… brain diseases like brain tumour have remained formidable owing to poor prognosis and the
challenging drug delivery to the brain … in brain-specific delivery of chemotherapeutic agents. …

… spare normal tissue and destroy tumour cells, is changing the … of drugs to tumours of the
central nervous system, discuss current trends and directions in the development of novel drugs …

… the blood–brain barrier and the blood–brain tumour barrier. This review will discuss the
challenges of drug delivery across the blood–brain barrier/blood–brain tumour barrier to cancer …

… drug carriers has also been reported to facilitate the infiltration into tumour interstitium through
the leaky tumour … Patients with primary brain tumours and brain metastases have a very …

… to brain tumours owing to different strategies, including chemical stabilization of the drug in
… leaky vascularization at the tumour site); inhibition of drug efflux mechanisms in endothelial …

… In this review, we summarize the recently investigated nanodrug carrier platforms for brain
tumor … were used as a drug carrier with improved penetration ability for effective drug delivery. …

… to the treatment of brain tumours based on their … drugs that were generally not toxic and
targeted at tumour cells. There have been numerous attempts to deliver drugs locally in the brain. …

… of knowledge in this field and potential strategies to improve drug delivery to brain tumours.
… macromolecules, in use for brain tumours and advances in drug design for brain tumours. …

… In this review we have discussed the approaches to drug delivery for brain tumours that
are currently under investigation in preclinical and/or clinical studies. Although some of these …

… Non-Stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol))
nanoparticles as injectable drug carriers J Control Rel 1995; 36: 49–61. 18. Ramos-Cabrer P, …