… cross-linkers was … hydrophilicity, antigen binding, and in vitro potency. This work establishes
a versatile method for synthesizing multifunctional cross-linkers and identifies cross-linker …

… hydrophilic linkers suitable for conjugation of a thiol-containing cytotoxic agent. These linkers
… Although the ideal linker for all antibody–drug conjugates may not exist, we believe the …

… linker-drug architectures that improve the efficacy and stability of ADCs. In this context, the
use of hydrophilic linkers … of the most used cytotoxic drugs and positively impact the physical …

… –drug conjugate (ADC) based on the topoisomerase I inhibitor payload exatecan, using our
hydrophilic monodisperse polysarcosine (PSAR) drug-linker … about the drug-linker structure–…

… The hydrophilic linkers facilitated the conjugation of budesonide, a lipophilic glucocorticoid.
The ADC bearing the linker was active and selective in vitro but there has of yet been no in …

… drug-linker were generated with increasing DAR. This was done to evaluate whether increased
drug hydrophilicity … our experience, the drug-linkers were conjugated to two human IgG2 …

… Moreover, the high hydrophilicity of the linker was … diester linker drug is greater than 5
mg/mL). In an in vitro evaluation, ADCs containing pyrophosphate and triphosphate diester linkers …

… receptor affinity of the resulting antibody–drug conjugates (ADCs), we have demonstrated that
… this type of linker. In addition, while PEGylation augments linker hydrophilicity, this change …

… the conjugation of antibody and drug linker such as drug-to-antibody ratio and site of
conjugation. … the importance of linker hydrophilicity in the design for mAb-MGBA conjugates [111]. …

… that this effect was due to the hydrophobic character of the current ADC payloads and that
by masking the hydrophobic payloads by hydrophilic linker moieties DAR = 8 ADCs with …