Riboflavin-targeted drug delivery

M Darguzyte, N Drude, T Lammers, F Kiessling - Cancers, 2020 - mdpi.com
… the riboflavin carrier protein was discovered in the 1960s, the three riboflavin transporters
(… It has been shown that riboflavin transporters and the riboflavin carrier protein are …

Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
… of riboflavin has been studied for over a decade, little is known about the riboflavin transporters
… In this study, we investigated the expression pattern of riboflavin transporters in human …

Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier

Y Kubo, S Miki, S Akanuma, K Hosoya - Drug Metabolism and …, 2019 - Elsevier
… In addition, the present findings will be useful in developing an efficient retinal drug delivery
system with riboflavin-conjugated drugs, that will improve the treatment of retinal diseases, …

Current perspectives on the cellular uptake and trafficking of riboflavin

AB Foraker, CM Khantwal, PW Swaan - Advanced drug delivery reviews, 2003 - Elsevier
riboflavin conditions. Various transport modulator studies consistently suggest a highly
riboflavin … model that riboflavin absorption involves a carrier-mediated transporter has recently …

Influence of riboflavin targeting on tumor accumulation and internalization of Peptostar based drug delivery systems

M Darguzyte, R Holm, J Baier, N Drude… - Bioconjugate …, 2020 - ACS Publications
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to …
using riboflavin may enhance tumor accumulation and internalization of drug delivery systems…

[HTML][HTML] Utility of transporter/receptor (s) in drug delivery to the eye

SHS Boddu, J Nesamony - World Journal of Pharmacology, 2013 - wjgnet.com
… They were the first to establish functional evidence for the presence of a high affinity
riboflavin transporter in this in vitro cell model. The carrier-mediated active transport system was …

Bioengineered riboflavin in nanotechnology

N Beztsinna, M Solé, N Taib, I Bestel - Biomaterials, 2016 - Elsevier
… Due to these features RF attracted researchers in various fields from targeted drug delivery
… , its optical, photosensitizing properties, RF transporter systems and its role in pathologies. …

Riboflavin transport and metabolism in humans

M Barile, TA Giancaspero, P Leone, M Galluccio… - Journal of inherited …, 2016 - Springer
… Therefore, studies on recently identified human plasma membrane riboflavin transporters
are presented, together with those in which still unidentified mitochondrial riboflavin transporter

Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells

M Patel, RK Vadlapatla, D Pal, AK Mitra - Brain research, 2012 - Elsevier
… In the last few decades, transporter targeted drug delivery approach has gained considerable
attention for delivering drugs that are poorly permeable across physiological barriers. …

Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier

Y Kubo, S Yahata, S Miki, S Akanuma… - Drug metabolism and …, 2017 - Elsevier
… of the transporter-mediated delivery of riboflavin-conjugated drugs into the retina, … transporter
characterized as multivitamin transporter (SMVT/SLC5A6) is useful for the delivery of drugs