… drug development. In this Review, we objectively itemise the boundaries of therapeutic efficacy
in ulcerative colitis, … solutions to achieve better therapeutic outcomes in ulcerative colitis. …

… practical drug development toward more clinically relevant end points in ulcerative colitis. …
, focusing on adult drug development, and offer some of our viewpoints in the discussion. …

… In conclusion, efficient drug development in UC requires the reevaluation of conventional …
These methods should increase the efficiency of early drug development programs by …

… UC and to test novel drug/therapeutic candidates … IBD). Many mouse models are currently
available that mimic the two major subtypes of IBD (Crohn’s disease [CD] and ulcerative colitis […

… signals of drug efficacy in … ulcerative colitis clinical trials, we developed and validated a
disease activity index based on absence of rectal bleeding in patients with active ulcerative colitis …

… techniques available for drug testing in intestinal … development for the treatment of UC.
The authors searched the literature for ‘ulcerative colitis’ AND ‘preclinical’ OR ‘drug target/drug …

… Ulcerative colitis (UC) is a chronic idiopathic inflammatory … There are multiple classes of
drugs that are available and are used … of developing dysplasia secondary to longstanding colitis. …

… advances in drug development are … drugs. Breaking the therapeutic ceiling of efficacy in
UC will require marked advances in management extending well beyond drug development. …

… Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred
usually in the rectum and lower part of the colon as well as the entire colon. Drug … developing …

… In the second part, we cover the new strategies that are being developed, including new
targets and small-molecule drugs, and how these developments can be integrated into new …