… the protracted TB treatment duration. This review summarizes the current TB drug development
pipeline and proposes strategies for generating improved hits and leads in the discovery …

… to discovering new TB drugs, and what measures could be taken to reduce the long and
protracted clinical development of new drugs. … innovations in TB drug discovery and evolving …

… the efficiency of future TB drug discovery. Novel TB drug regimens with shorter treatment …
recent notable examples that may prove to be useful leads for TB drug discovery (Fig. 1). …

… Tuberculosis (TB) drug development has made substantial progress in the past decade.
There are currently at least ten drugs … at higher doses or in new drug combinations (rifamycins, …

… in approaching TB drug discovery with a broader range of assays and libraries being
developed and applied. However, some basic impediments to drug discovery remain, including …

… There is an urgent need to develop newer, potent and safer anti-tubercular agents which …
of tuberculosis and the drug development against TB as well as the recent drug development. …

… tuberculosis. Moreover, an insufficient understanding of host–… the recent successes in TB
drug development and attempt to … An emerging approach to target-based drug discovery is the …

… the development of new drugs. In this review, we highlight the reasons that make TB drug
discovery and development … directions and alternative approaches to new therapeutics for TB. …

… preclinical development to treat tuberculosis are reported in this review. … Drug discovery and
drug development … The number of TB drugs in preclinical and clinical development is today …

… -TB lead generation has much improved over the last decade, as exemplified by the recent
approval of bedaquiline and delamanid to treat MDR-TB and XDR-TB… in TB drug discovery in …