… due to the failure of alternative drug discovery methods to deliver many lead compounds …
drug discovery methods, and also to keep pace with the ongoing changes in the drug discovery …

… Use of a uniform definition for PDD helps to illuminate the impact of PDD on modern drug
discovery 1,6 , and underlines the importance and impact of empirical drug discovery …

… was targeted during the initial drug discovery effort. (52) Topiramate was first prepared from
d-fructose as part of an antidiabetic drug discovery program targeting the enzyme fructose-1,…

… for drug discovery and development. We define how this blossoming field has already
impacted the pharmaceutical industry and describe how it can further enhance the drug discovery …

… The process of drug discovery encompasses a period of intense R&D effort that typically
spans 13–15 yr, and involves: (i) search for a target to start a programme or project, (ii) lead …

… Non-profit organizations (NPO) play an increasingly important role in drug discovery and …
Drug discovery in the field of neglected diseases is fraught with complexities since, in many …

… technologies in drug discovery programs. These … discovery. This paper provides a brief
perspective on the evolution and use of key drug design technologies, highlighting opportunities …

… product-based drug discovery, highlight selected applications and discuss key opportunities.
… In the concluding section, we highlight promising future directions for NP drug discovery. …

… major challenges and opportunities of polypharmacology in drug discovery. In … drug
promiscuity arising from off-target effects, drug repurposing, and rational design of multitarget drugs…

… of topics relevant to the process of drug development and discovery, the current communication
… scientists over the course of drug discovery and development. Pre-discovery challenges …