A Self-Assembled “Albumin–Conjugate” Nanoprobe for Near Infrared Optical Imaging of Subcutaneous and Metastatic Tumors

W Wang, Z Fang, X Zhang, H Cai, Y Zhao… - ACS Applied Bio …, 2019 - ACS Publications
… Our novel nanoprobe is composed of human serum albumin (… (Erlotinib) by covalent bonding.
This conjugate could bind to … composed of an anti-EGFR drug (Erlotinib) and a NIR hypoxia…

Evaluation of the interaction of novel tyrosine kinase inhibitor apatinib mesylate with bovine serum albumin using spectroscopies and theoretical calculation …

SB Kou, ZY Lin, BL Wang, JH Shi… - Journal of Biomolecular …, 2021 - Taylor & Francis
… A spectroscopic study on the interaction between the anticancer drug erlotinib and human
serum albumin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 78(1-4), 405–…

Drug interactions between tyrosine kinase inhibitors (gefitinib and erlotinib) and warfarin: assessment of international normalized ratio elevation characteristics and in …

M Hiraide, Y Minowa, Y Nakano… - Journal of Oncology …, 2019 - journals.sagepub.com
… Up to now, no data on the effect of gefitinib and erlotinib on … effects of drugdrug interaction
between warfarin–gefitinib or -erlotinib … In addition, using human liver microsomes in vitro, we …

… studies on the interaction of ds-DNA with anti-cancer agents imatinib and erlotinib–Comparison of Au and Pt nanoparticle effects to drug-DNA complex formation

DE Bayraktepe, C Yıldız, Z Yazan - Journal of Molecular Liquids, 2023 - Elsevier
Erlotinib (ERL) are two tyrosine kinase inhibitors used to treat a slow-growing type of blood
… The action of these drugs is based on their interaction with the guanine moieties on the DNA…

Characterizing the binding interaction between erlotinib and calf thymus DNA in vitro using multi‐spectroscopic methodologies and viscosity measurement combined …

XJ Chen, BL Wang, KL Zhou, YY Lou, SB Kou… - …, 2019 - Wiley Online Library
… Absorption spectroscopy is a very effective approach for assessing ligands or drugs
binding to biomacromolecules like serum albumin and DNA. DNA is composed of four …

Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer

B Vaidya, V Parvathaneni, NS Kulkarni… - International journal of …, 2019 - Elsevier
… (C) In-vitro drug release profile of erlotinib from plain erlotinib (ER-F3) and Erlo-CD
complex (ER-CD-F4) loaded nanoparticle in PBS (pH 7.4). Data represent mean ± SD (n = 3). …

Development and mechanistic insight into the enhanced cytotoxic potential of parvifloron D albumin nanoparticles in EGFR-overexpressing pancreatic cancer cells

A Santos-Rebelo, P Kumar, V Pillay, YE Choonara… - Cancers, 2019 - mdpi.com
Erlotinib conjugated NPs presented the highest … In fact, albumin is the most abundant protein
in blood plasma, being … Bovine serum albumin (BSA) was chosen as encapsulating material…

Reversing chemotherapy resistance by a synergy between lysosomal pH-activated mitochondrial drug delivery and erlotinib-mediated drug efflux inhibition

F Cheng, Q Pan, W Gao, Y Pu, K Luo… - ACS Applied Materials & …, 2021 - ACS Publications
… escape and mitochondrial-targeting drug delivery, leading to … supply and erlotinib enabled
dual inhibition of drug efflux by … of mitochondrial drug delivery and drug efflux inhibition …

Erlotinib: as maintenance monotherapy in non-small-cell lung cancer

VJ Muir, S Dhillon - BioDrugs, 2011 - Springer
Erlotinib is a low molecular weight, orally active, epidermal … In the well designed, phase
III SATURN study, oral erlotinib … PFS was significantly longer with erlotinib than with placebo …

Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation

MA Elmeliegy, AM Carcaboso, M Tagen, F Bai… - Clinical Cancer …, 2011 - AACR
… Because HPBCD forms inclusion complexes with erlotinib in the perfusate limiting drug
movement to brain ECF, we could not use retrodialysis or no net flux to estimate in vivo recovery …