Drug eruptions with novel targeted therapies–immune checkpoint and EGFR inhibitors

I Pospischil, W Hoetzenecker - JDDG: Journal der Deutschen …, 2021 - Wiley Online Library
… skin reactions with immune checkpoint inhibitors are non-specific maculopapular exanthemas
that resemble the ‘classic’ maculopapular drug rashes. Lichenoid drug eruption may …

The management of EGFR inhibitor adverse events: a case series and treatment paradigm

AM Wnorowski, A de Souza… - International journal …, 2012 - Wiley Online Library
… This was consistent with a drug reaction. … The most common cutaneous adverse event
triggered by EGFR inhibitors in our cohort of cases was a papulopustular rash (80%). This finding …

[HTML][HTML] EGFR inhibitors and cutaneous complications: a practical approach to management

LM Guggina, AW Choi, JN Choi - Oncology and Therapy, 2017 - Springer
… Fortunately, with EGFRI therapy, severe drug eruptions such as Stevens–Johnson syndrome
(SJS) and toxic epidermal necrolysis (TEN) are exceedingly rare, but they have been …

[HTML][HTML] Expert consensus on the management of adverse events from EGFR tyrosine kinase inhibitors in the UK

R Califano, N Tariq, S Compton, DA Fitzgerald… - Drugs, 2015 - Springer
… In case of grade 3 rash, EGFR-TKI therapy should be temporarily … EGFR-TKI for prescribing
advice [18–20, 24, 26, 27]. We recommend restarting EGFR-TKI therapy only when the rash

Epidermal growth factor receptor inhibitors: a new era of drug reactions in a new era of cancer therapy

EW Cowen - Journal of the American Academy of Dermatology, 2007 - jaad.org
… The high incidence of EGFR inhibitor–induced cutaneous reactions is not unanticipated in …
use of the EGFR inhibitors and the high incidence of cutaneous reactions, our understanding …

Cutaneous drug eruptions associated with the use of new oncological drugs

B Belloni, N Schönewolf, S Rozati… - … Drug Eruptions, 2012 - karger.com
… BRAF inhibitors can lead to rash and development of cutaneous keratinocytic neoplasias
for … inhibitors induce similar skin toxicities to EGFR inhibitors such as papulopustular rashes, …

Managing treatment-related adverse events associated with EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer

V Hirsh - Current Oncology, 2011 - mdpi.com
… , the most common adverse events of the EGFR inhibitors are rash and diarrhea, which are
the … and management of EGFR-TKI–related adverse events such as rash and diarrhea should …

Safety and tolerability of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in oncology

RR Shah, DR Shah - Drug safety, 2019 - Springer
… The selectivity and reversibility for EGFR inhibition by the currently … rash. This strategy is
predicated on the hypothesis that inhibition of EGFR in skin correlates with inhibition of EGFR

Epidermal growth factor receptor inhibitors: a review of cutaneous adverse events and management

K Chanprapaph, V Vachiramon… - Dermatology …, 2014 - Wiley Online Library
… severity rash from EGFR inhibitors [27]. … rashes are dose dependent [29]. Therefore, gradual
dose increment until the skin eruptions appears is a strategy to maximize efficacy of EGFR

[HTML][HTML] Drug-drug interactions, safety, and pharmacokinetics of EGFR tyrosine kinase inhibitors for the treatment of non–small cell lung cancer

CR Kucharczuk, A Ganetsky… - Journal of the Advanced …, 2018 - ncbi.nlm.nih.gov
EGFR TKIs for NSCLC. Erlotinib and gefitinib are reversible EGFR inhibitors that bind to both
wild-type and mutant EGFR, … binds to wild-type and mutant EGFR, as well as to the ErbB …