… drug-like compounds have all contributed to the introduction of several novel alternative lead
… In this article, we consider HTS-based lead discovery to be HTS of large lead-like or drug-…

… it relatively easy to identify initial lead candidates for new drug targets [1]. High … drug
candidate. Chemists at Pfizer developed the so-called rule of five for leads and drug candidates [2]. …

… drug design. However, in vitro methods are certainly important to the understanding of the
specific factors contributing to drug … during drug discovery for lead optimization and candidate …

… the best potential clinical candidate. We introduce the concept of drug efficiency as a new
tool both to guide the drug discovery program teams during the lead optimization phase and to …

… cruzi strains may respond differently to a chemotherapy, 19,20 we believe a drug … lead
series are also being evaluated, and we aim to define two or three preclinical candidates …

… A tosylate salt was identified as a promising candidate for further evaluation. This case study
provides an example of identification of a less common salt of an insoluble drug, leading to …

… engaged in drug design. Strategies to prolong the oral t 1/2 of a promising candidate drug
via … administration, which is often a key objective during hit-to-lead phases of drug discovery. …

… and progress the drug candidate with the best overall drug safety profile … drug candidate
with the best overall drug safety profile for a therapeutic area, [b] remove the severely toxic drugs …

… in the research of new drugs and medicines redirected the … of obtaining new hits
candidate to drug prototypes, which … the physicochemical properties of drugs and lead-compounds …

… drug substitute among available favorite drug candidates that … to find the potential drug
candidates and their precise … of antimicrobial peptides and the lead derivatives of coumarin, …