… of hCES inhibitors from clinically available medications, as well as their impact on CES-associated
drug metabolism. Three comprehensive lists of hCES inhibitors deriving from …

… drug metabolism and clearance [14, 15]. Because of the critical role of CES1 in metabolizing
cholesteryl esters [16], inhibitors … but exhibit distinct substrate and inhibitor specificity [7, 18]. …

… interaction is between clopidogrel and oseltamivir, both hCE1 substrates that appear to
participate in substantial competitive inhibition for the same carboxylesterase. It was reported …

… Considering that several of the dihydropyridine calcium channel blockers are inhibitors of
CES1, carboxylesterases may at least contribute to the metabolism of these drugs. …

… Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism …
Selective hCE1 inhibitors targeted to several sites on the enzyme may also pave the way for …

… Hence, modulation of CE activity may present an opportunity to alter drug metabolism and
pharmacokinetics, with the ultimate goal of improving therapy. With this goal in mind, small …

… , drug metabolism and toxicity, there is a great deal of interest in the discovery and development
of potent and selective inhibitors against carboxylesterases … against carboxylesterases, …

… is drug–drug interactions that inhibit CES function. The importance … inhibition of drug
metabolism in medication safety and efficacy is well established for drugs that undergo metabolism …

… This review identifies carboxylesterase substrates and describes our current understanding
… no carboxylesterase genotypes referenced in Food and Drug Administration approved drug …

… of structural similarities of CES1 inhibitors. In conclusion, drug–drug interactions with
MPH are likely mediated via CES1 inhibition as a result of concomitant drug therapies. CES1 …