… carboxylesterases in drug metabolism may not be fully appreciated as an important health
issue and the widely held assumption that carboxylesterase-… activity of specific drugs may not …

… The two most significant forms of CESs in humans for drug metabolism are CES1 and
CES2 [1, 2, 6-8]. Interestingly, CESs could serve as both drugs and drug targets [9]. CES1 is …

… Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and
… These are the first structures of a human carboxylesterase, and they provide details about …

… Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in
the metabolism of several important therapeutic agents, drugs of … the role of human CES1 in …

… analysis of the alcohol-carboxylesterase drug interaction. Oseltamivir is a … metabolic
pathways that we chose as a probe drug to avoid the confounding effects of competing metabolic …

… on CES-associated drug metabolism. Three comprehensive lists of hCES inhibitors deriving
from clinically available medications including therapeutic drugs, pharmaceutical excipients …

… hCE1, pure recombinant human carboxylesterase 1 protein; HLC, pooled human liver cytosol;
HLM, pooled human liver microsomes; hCE2, human carboxylesterase 2. Equal amounts …

… the metabolic pathways of carboxylesterase-substrate drugs and the influence of specific
genotypes on drug … As our understanding of carboxylesterase drug metabolism progresses it is …

… 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE, HU3) are a serine esterase
involved in both drug metabolism and activation. Although both hCE-1 and hCE-2 are …

… In addition to drug metabolism, CES also participate in the detoxification and metabolic
clearance of many ester-containing toxicants, such as the pyrethroid insecticides (deltamethrin …