Non-clinical models to determine drug passage into human breast milk

D Ventrella, M Forni, ML Bacci… - Current Pharmaceutical …, 2019 - ingentaconnect.com
breastfeeding when their mothers are prescribed medication … governing drug transfer rates
into human breast milk and the … drug properties may provide a rough estimation of blood/milk

Molecular descriptors that influence the amount of drugs transfer into human breast milk

S Agatonovic-Kustrin, LH Ling, SY Tham… - … of Pharmaceutical and …, 2002 - Elsevier
… Most drugs are excreted into breast milk to some extent and … of drug that might be present
in milk from the drug structure … to select descriptors that effect drug passage into breast milk. …

Drug excretion in breast milk

H Vorherr - Postgraduate Medicine, 1974 - Taylor & Francis
… pores may permit passage of watersoluble drug molecules with … , drugs contained in breast
milk may cause idiosyncrasy. For instance, hemolytic anemia induced by drugs in breast milk

Drugs and chemical contaminants in human breast milk

A Anadón, MR Martínez-Larrañaga, I Ares… - Reproductive and …, 2017 - Elsevier
… the extent of drug excretion in human breast milk is not available and for many drugs data
from … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage

Principles of drug transfer into breast milk and drug disposition in the nursing infant

RL Breitzka, TL Sandritter… - Journal of human …, 1997 - journals.sagepub.com
… to drug passage into breast milk. Pharmacokinetics is the study of drug movement throughout
the body… More specifically it is the study of the relationship between drug dosage and drug

[HTML][HTML] An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk

T Zhang, Z Applebee, P Zou, Z Wang, ES Diaz… - International Journal of …, 2022 - Elsevier
breastfeeding infants and did not take any medications. The process of human breast milk
… IRB) and all donors signed the informed consent before donating the breastmilk. Expressed …

[HTML][HTML] Drug distribution in human milk

KF Ilett, JH Kristensen… - Australian …, 1997 - australianprescriber.tg.org.au
… of drugs and environmental chemicals into human milk continues … aware of the possible risks
to the breast-fed infant. There is … passage of low molecular weight heparin into human milk

Passage of paracetamol into breast milk and its subsequent metabolism by the neonate.

LJ Notarianni, HG Oldham… - British journal of clinical …, 1987 - Wiley Online Library
… of paracetamol received in milk is dependent on milk flow and is a variable that should be
taken into account in the design and interpretation of studies of drug passage into breast milk. …

Modeling drug passage into human milk

PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
drug passage into breastmilk is the administration of a drug to a … the drug therapeutically.
After administration, several timed … milk with a breast pump can overestimate the volume of milk

Biological barriers, and the influence of protein binding on the passage of drugs across them

K Wanat - Molecular biology reports, 2020 - Springer
… also bind with the breast milk proteins themselves [112]. The composition of the protein …
drug binding is typically weaker in breast milk than in plasma [111]. Drug transfer into breast milk