Modeling drug passage into human milk
PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
… human studies can reliably quantify drug passage into breastmilk. The standard method of
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug …
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug …
Non-clinical models to determine drug passage into human breast milk
… drug passage into human milk’, ie. assessment or prediction of (variability of) drug
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …
[HTML][HTML] Drug distribution in human milk
KF Ilett, JH Kristensen… - Australian …, 1997 - australianprescriber.tg.org.au
… The distribution of drugs and environmental chemicals into human milk continues to be an
… drugs are considered safe. The passage of low molecular weight heparin into human milk …
… drugs are considered safe. The passage of low molecular weight heparin into human milk …
[HTML][HTML] A comprehensive review on non-clinical methods to study transfer of medication into breast milk–A contribution from the ConcePTION project
N Nauwelaerts, N Deferm, A Smits, C Bernardini… - Biomedicine & …, 2021 - Elsevier
… transfer of medication into the human milk. However, reliable … in culture for at least 15 passages
and could represent a good … often applied to predict drug-drug interactions and to select …
and could represent a good … often applied to predict drug-drug interactions and to select …
Studying drugs in human milk: time to unify the approach
EJ Begg, SB Duffull, LP Hackett… - Journal of Human …, 2002 - journals.sagepub.com
… on drug transfer into human milk and the extent to which the suckling neonate may be exposed
to, and affected by, unwanted xenobiotics. After excluding drugs that … the passage of drug …
to, and affected by, unwanted xenobiotics. After excluding drugs that … the passage of drug …
Developing an in vitro to in vivo extrapolation (IVIVE) model to predict human milk-to-plasma drug concentration ratios
… Determining the amount of drug transferred into human milk is critical for benefit–risk analysis
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …
Models and methods for predicting drug transfer into human milk
JC Fleishaker - Advanced drug delivery reviews, 2003 - Elsevier
… for predicting drug transfer into milk in humans. These … that control drug partitioning between
milk and plasma. In vivo … that may either transport drugs into or out of breast milk. Finally, …
milk and plasma. In vivo … that may either transport drugs into or out of breast milk. Finally, …
Prediction of drug distribution into human milk from physicochemical characteristics
UC Atkinson, EJ Begg - Clinical pharmacokinetics, 1990 - Springer
… Steady-State Assumptions These models all assume that the rate of drug passage across
the membrane between milk and pl:lsma is relallvely rapid and that equilibrium be· tween …
the membrane between milk and pl:lsma is relallvely rapid and that equilibrium be· tween …
Selective serotonin reuptake inhibitors' passage into human milk of lactating women
L Pogliani, S Baldelli, D Cattaneo, P Pileri… - The Journal of …, 2019 - Taylor & Francis
… the passage of these drugs into human milk, often with conflicting results. Here, we sought
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …
Drugs and chemicals in human milk
CM Berlin, GG Briggs - Seminars in fetal and neonatal medicine, 2005 - Elsevier
… Most drugs and many chemicals will be transferred into milk. … of the transfer of drugs into
milk, discusses the importance of the … of maternal conditions for which drugs need to be used. …
milk, discusses the importance of the … of maternal conditions for which drugs need to be used. …
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