… enter milk during its formation, the effects of drugs on the milk … , the main determinants of
drug excretion into milk and their … drugs, describing the extent of their passage into human milk, …

… This chapter discusses three major components that affect drug transfer into human milk and
the … The passage of drug from maternal ingestion to the infant begins with the ingestion of …

… , drugs become ion trapped in milk. Due to the lower pH of human milk, the physicochemical
structure of the drug … step was to select descriptors that effect drug passage into breast milk. …

… The principles of drug passage into … drug does not affect the quantity and/or quality of human
milk and there is reasonable certainty either that the drug is not detectable in human milk or …

… Despite significant efforts to improve drug labeling for medication use during lactation, there
remains a paucity of pharmacokinetic data in human milk. Among the drug labels approved …

… to drug passage into breast milk. Pharmacokinetics is the study of drug movement throughout
the body… More specifically it is the study of the relationship between drug dosage and drug …

… drugs in some instances equals or exceeds the plasma level (table 1). When the pH of plasma
and human milk changes, the degree of drug … may permit passage of watersoluble drug …

… the transfer of drugs and chemicals into human milk. This … agents transferred into human milk
and their possible effects … that it is not transferred into human milk or that it does not have an …

… data, if known, concerning the excretion of drugs into human milk. Most drugs likely to be
prescribed to the nursing mother should have no effect on milk supply or on infant well-being. …

… 5 A limited amount of data, mainly single assessments at heterogeneous time points after
delivery, are available on the distribution of venlafaxine in human milk and on drug exposure …