… drugs and chemicals into human milk continues to become available. This current statement
is intended to revise the lists of agents transferred into human milk … into human milk or that it …

… differences in milk characteristics between the human and other … determine the passage of
drugs and chemicals into human milk. … of the composition and the constituents of human milk. …

… Non-clinical methods have the potential to generate quantitative data in an early (drug …
Information regarding the extent and rate of passage of medicines across the blood–milk …

… drugs between a fat-rich and a lowfat phase of human milk, and to subject the low-fat milk
to … It can be assumed that the drugs had free passage through the dialysis membrane, since …

… with a high free plasma fraction, while the relatively low pH of human milk (7.0–7.2) favors
the accumulation of weakly basic drugs. Finally, drug passage into the human milk is not …

… binding of drugs in human milk is less … milk, while the bound fraction stays in the maternal
plasma unable to reach the tissues. For drugs, which are actively transported into human milk, …

… Therefore, to improve our understanding of the effect of drugs on milk production and … drugs,
an accurate and reliable approach that can be used to estimate drug passage to human milk …

… due to the high molecular mass of the drug-protein complex, thus resulting in the … drug-protein
binding on drug transport across physiological barriers, whose role is to allow the passage …

… to concerns of drug exposure risks to the infant through milk. Currently, there are no consistent
and standardized practices for the collection and drug analysis in human milk. This thesis …