… Drugs with high molecular weights, such as heparin and many new biological drugs, are
mostly excluded from the intact milk compartment. The transfer of drugs into human milk is …

… drug excretion in breast milk: maternal drug disposition, breast milk pharmacokinetics and
neonatal drug … on drug dose to infant whereas the last area is crucial to drug accumulation in …

… serum protein may contribute to drug excretion into human milk. The nonionized fraction of
any … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage …

… drugs in human milk, the pharmacokinetic data for this biological matrix, the adverse effects
these drugs … The passage of THC into breast milk has been studied in animals, but the only …

… drug used to treat partial-onset seizures. Limited information is currently available on the
transfer of lacosamide to breast milk. … to quantify lacosamide in human breast milk and plasma …

… approach to predict transfer of medicines into human milk, along with neonatal systemic
exposure. … These primary cells can be maintained in culture for at least 15 passages and could …

… milk is more acidic than plasma Citation[2]. Milk contains more lipid than plasma, thus drugs
… of the drug, infant suckling pattern, composition of the milk, maternal dosage, half-life of the …

… The tendency for a drug to accumulate in human milk is almost never known when a drug …
that factors influencing the passage of a drug from plasma into human milk included (i) size …

… the milk/plasma ratio of various drugs in human subjects. Potentially adverse effects of various
drugs present in human milk … ) Passage of pentobarbital into bovine and caprine milk after …

… Protein binding impedes the transmembrane passage and decreases the drug … properties
of drugs into human milk, some molecular descriptors for basic drugs were identified as the …