[HTML][HTML] Drug response prediction by ensemble learning and drug-induced gene expression signatures

M Tan, OF Özgül, B Bardak, I Ekşioğlu, S Sabuncuoğlu - Genomics, 2019 - Elsevier
… method to predict drug response. In addition, we attempt to use the drug screen data
together with two novel signatures produced from the drug-induced gene expression profiles of …

Gene signatures of drug resistance predict patient survival in colorectal cancer

Y Zheng, J Zhou, Y Tong - The pharmacogenomics journal, 2015 - nature.com
… the genes regulating cancer cell response to these anti-cancer drugs, we combined
microarray data of drug resistance with data of patient survival. Three gene signatures were …

Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma

H Yin, Q He, J Chen, Z Li, W Yang… - Journal of Clinical …, 2021 - Wiley Online Library
… proposed an eight-gene signature related to drug metabolism as a potential biomarker to
predict the prognostic risk of gastric adenocarcinoma patients. The predicted drugs (niacin and …

Drug target prediction through deep learning functional representation of gene signatures

H Chen, FJ King, B Zhou, Y Wang, CJ Canedy… - Nature …, 2024 - nature.com
… in existing gene signature comparison algorithms can enhance our understanding of how
transcriptional data can be employed to predict … to their progression in drug discovery, effective …

[HTML][HTML] Developing a genetic signature to predict drug response in ovarian cancer

S Hyter, J Hirst, H Pathak, ZY Pessetto, DC Koestler… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… We propose that efficacious drug combinations can be … To that end, we selectively performed
multiple two-drug … of proliferative inhibition to a specific drug combination of auranofin and …

A necroptosis‐related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma

J Chen, H Wang, L Zhou, Z Liu, H Chen… - Cancer …, 2022 - Wiley Online Library
… To better link the necroptosis-related gene signature with clinical practice, we used the “oncoPredict”
package to predict sensitivities to commonly used drugs for HCC. The results …

SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures

Z Zuo, P Wang, X Chen, L Tian, H Ge, D Qian - BMC bioinformatics, 2021 - Springer
… We predicted the \(IC_{50}\) based on gene signatures and molecular graphs and achieved
better predictive performance than methods reported in previous literatures. We used the self…

A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity

MR Fielden, BP Eynon, G Natsoulis… - Toxicologic …, 2005 - journals.sagepub.com
… To summarize, we have derived a gene signature that is designed to predict the future
development of renal tubular degeneration before it appears histologically or by other traditional …

PREDICT: a method for inferring novel drug indications with application to personalized medicine

A Gottlieb, GY Stein, E Ruppin… - Molecular systems biology, 2011 - embopress.org
… the drug targets. We further show that disease‐specific genetic signatures can be used to
accurately predict drug … personalized drug treatments, where gene expression signatures from …

Development of a CAFs-related gene signature to predict survival and drug response in bladder cancer

Z Zhang, Z Liang, D Li, L Wang, Y Chen, Y Liang… - Human Cell, 2022 - Springer
… In summary, we constructed a CAFs-related gene signature to predict the prognosis for
bladder cancer. The signature contains five genes that are highly expressed in fibroblasts and …