[HTML][HTML] Drug response prediction by ensemble learning and drug-induced gene expression signatures
… method to predict drug response. In addition, we attempt to use the drug screen data
together with two novel signatures produced from the drug-induced gene expression profiles of …
together with two novel signatures produced from the drug-induced gene expression profiles of …
Gene signatures of drug resistance predict patient survival in colorectal cancer
Y Zheng, J Zhou, Y Tong - The pharmacogenomics journal, 2015 - nature.com
… the genes regulating cancer cell response to these anti-cancer drugs, we combined
microarray data of drug resistance with data of patient survival. Three gene signatures were …
microarray data of drug resistance with data of patient survival. Three gene signatures were …
Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma
H Yin, Q He, J Chen, Z Li, W Yang… - Journal of Clinical …, 2021 - Wiley Online Library
… proposed an eight-gene signature related to drug metabolism as a potential biomarker to
predict the prognostic risk of gastric adenocarcinoma patients. The predicted drugs (niacin and …
predict the prognostic risk of gastric adenocarcinoma patients. The predicted drugs (niacin and …
Drug target prediction through deep learning functional representation of gene signatures
… in existing gene signature comparison algorithms can enhance our understanding of how
transcriptional data can be employed to predict … to their progression in drug discovery, effective …
transcriptional data can be employed to predict … to their progression in drug discovery, effective …
[HTML][HTML] Developing a genetic signature to predict drug response in ovarian cancer
… We propose that efficacious drug combinations can be … To that end, we selectively performed
multiple two-drug … of proliferative inhibition to a specific drug combination of auranofin and …
multiple two-drug … of proliferative inhibition to a specific drug combination of auranofin and …
A necroptosis‐related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma
J Chen, H Wang, L Zhou, Z Liu, H Chen… - Cancer …, 2022 - Wiley Online Library
… To better link the necroptosis-related gene signature with clinical practice, we used the “oncoPredict”
package to predict sensitivities to commonly used drugs for HCC. The results …
package to predict sensitivities to commonly used drugs for HCC. The results …
SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures
Z Zuo, P Wang, X Chen, L Tian, H Ge, D Qian - BMC bioinformatics, 2021 - Springer
… We predicted the \(IC_{50}\) based on gene signatures and molecular graphs and achieved
better predictive performance than methods reported in previous literatures. We used the self…
better predictive performance than methods reported in previous literatures. We used the self…
A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity
MR Fielden, BP Eynon, G Natsoulis… - Toxicologic …, 2005 - journals.sagepub.com
… To summarize, we have derived a gene signature that is designed to predict the future
development of renal tubular degeneration before it appears histologically or by other traditional …
development of renal tubular degeneration before it appears histologically or by other traditional …
PREDICT: a method for inferring novel drug indications with application to personalized medicine
A Gottlieb, GY Stein, E Ruppin… - Molecular systems biology, 2011 - embopress.org
… the drug targets. We further show that disease‐specific genetic signatures can be used to
accurately predict drug … personalized drug treatments, where gene expression signatures from …
accurately predict drug … personalized drug treatments, where gene expression signatures from …
Development of a CAFs-related gene signature to predict survival and drug response in bladder cancer
Z Zhang, Z Liang, D Li, L Wang, Y Chen, Y Liang… - Human Cell, 2022 - Springer
… In summary, we constructed a CAFs-related gene signature to predict the prognosis for
bladder cancer. The signature contains five genes that are highly expressed in fibroblasts and …
bladder cancer. The signature contains five genes that are highly expressed in fibroblasts and …
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