… 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as …
of a human carboxylesterase, and they provide details about narcotic metabolism in humans. …

… Carboxylesterases catalyze the hydrolysis of a wide variety of endogenous and exogenous
… of this review is drug substrates of carboxylesterases, and almost all known drugs that are …

… Human carboxylesterases (CES) play crucial roles in both endo- and xenobiotic metabolism…
of ester drugs. This review covers the structural and catalytic features of human CES, tissue …

… Human carboxylesterase 1 (hCE1) exhibits broad substrate specificity and is involved in
xenobiotic processing … cholesterol-lowering drug mevastatin, the breast cancer drug tamoxifen, …

… At present, the crystal structures of several mammalian carboxylesterases including hCES1A
have been reported [19]. The crystal structures of hCES1A complexed with different ligands …

… , MR: Structural insights into drug processing by human carboxylesterase 1: Tamoxifen, …
of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug. …

… In addition, we showed that hCE1 Human carboxylesterase … in complex with tacrine, the first
drug approved for treating … play a role in the necrotic Human carboxylesterase 1 (hCE1) is a …

… liver cytosol; HLM, pooled human liver microsomes; hCE2, human carboxylesterase 2. Equal
amounts … Human carboxylesterase isozymes: Catalytic properties and rational drug design. …

… (including clinically used drugs, prodrugs, abused drugs, and organophosphorus nerve … to
be a drug target, as well as functioning as a drug itself. To use CE-1 itself as a drug, it might be …

… Human carboxylesterase 1 (hCE1) is a drug and endobiotic-processing serine hydrolase
that exhibits relatively broad substrate specificity. It has been implicated in a variety of …