… enzymatic targets for AD, like β- and γ-secretases, sirtuins, caspase proteins and glycogen
synthase kinase-3 (GSK-3). In addition, new mechanistic rationales for drug … recent enzymatic …

… Thus, this enzyme has emerged as a promising target to treat TB. The screening of 1500
molecules from the AstraZeneca library identified the compound dihydrobenzofuranyl urea (78) …

… efficient antihypertensive drugs were inhibitors of the angiotensinconverting enzyme (ACE), …
of the resistance to the treatment by multi-target drugs. On the other hand, the inferior …

… enzyme active site, blocking the access of the ligand to the binding site, although the new
ligand was capable to reach the enzymatic target with adequate lipophilicity (log P = 3.35) [12]. …

… has since remained a prototype for a proteolytic cascade in … drug targets, and to be able to
validate them as targets and … zinc moiety in the enzyme's active site; and they target only the S1…

… New medicines are designed to bind to receptors or enzymes and are tested in animal cells,
… has already led to an explosion of potential drug targets. These may not have led to the …

… to target specific enzymes or carriers by considering enzyme-substrate specificity or
carrier-substrate specificity in order to overcome various undesirable drug … active prototypes or …

… enzymes of this family are very important targets for therapeutic interventions, while others
have a fundamental role in the metabolism of drugs and … ) receptor, the prototype of the ligand-…

… tyrosine phosphatase dysfunction and use some prototype contemporary strategies to illustrate
… protein drug targets into three major groups. The most common drug targets are enzymes …

… The ideal target typically is an enzyme with fully elucidated function and mechanism (Table …
structure is circularly permuted relative to prototype GTPases such as Ras. Biochemical …