Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

SR Lord, AL Harris - British Journal of Cancer, 2023 - nature.com
… As has typically been the case drug repurposing programmes, the interest in metformin was
… were less likely to develop cancer compared to patients on other diabetes drugs [5]. This …

Drug repurposing for the treatment of acute myeloid leukemia

V Andresen, BT Gjertsen - Frontiers in Medicine, 2017 - frontiersin.org
… Also the heterogeneity of AML will likely demand a broader repertoire of therapeutic molecules.
Drug repurposing or repositioning represent a source for potential therapeutics with well-…

[HTML][HTML] Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges

JA Malik, S Ahmed, B Jan, O Bender… - Biomedicine & …, 2022 - Elsevier
… the drug repurposing with a major focus on breast cancer. BC is a division of cancer known
as … The sluggish progression in developing new therapeutic drugs is partly due to the safety …

Drug repurposing in oncotherapeutics

A Patel - Drug repurposing: hypothesis, molecular aspects and …, 2020 - books.google.com
… or inhibition of proliferation in proper cell culture environment of different cancer cells [46–48].
Also, genetic expression study of drugs based on cell line can help in drug repurposing. …

Drug repurposing towards targeting cancer stem cells in pediatric brain tumors

HF Bahmad, MK Elajami, T El Zarif… - Cancer and Metastasis …, 2020 - Springer
… While majority of cancer cells within a … therapeutic agents prompting cancer recurrence
with time. This renders the need for novel targeted therapeutic approaches for “repurposed drugs

Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention

A Ozleyen, YB Yilmaz, S Donmez, HN Atalay… - Journal of Cancer …, 2023 - Springer
… indicate new therapeutic targets, thereby identifying novel therapeutic actions for already
approved medicines, which is called drug repurposing. The strategy of drug repurposing, also …

Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing

RR Malla, S Viswanathan, S Makena, S Kapoor… - Cancers, 2024 - mdpi.com
… for established drugs. By examining the multifaceted landscape of drug repurposing, this
review aims to offer comprehensive insights into its potential to transform cancer therapeutics. …

A database of drug repurposing clinical trials in oncology

P Pantziarka, L Vandeborne, G Bouche - Frontiers in Pharmacology, 2021 - frontiersin.org
… types to the exploration of non-cancer drugs as new cancer therapeutics (Pushpakom … -cancer
drugs as potential cancer therapeutics. To this end the list of drugs classed as repurposing

Targeting autophagy by antipsychotic phenothiazines: potential drug repurposing for cancer therapy

RM Lopes, ACS Souza, M Otręba… - Biochemical …, 2024 - Elsevier
… However, despite the promising initial results, available cancer therapeutics have limitations
that hinder its clinical use or reduce its effectiveness. Although all currently available …

Adopting drug repurposing to overcome drug resistance in cancer

E Shankar, V Subramaniam… - Frontiers in Cell and …, 2023 - frontiersin.org
… several therapeutics, but the entire process is tedious. Drug repurposing, also called drug
… opportunities to use approved or investigational drugs that are outside the scope of the …